Neural crest cells organize the eye via TGF-β and canonical Wnt signalling

In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model sy...

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Main Authors:	Grocott, Timothy, Johnson, Samuel, Bailey, Andrew P., Streit, Andrea
Format:	Online
Language:	English
Published:	Nature Publishing Group 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104559/

id	pubmed-3104559
recordtype	oai_dc
spelling	pubmed-31045592011-06-01 Neural crest cells organize the eye via TGF-β and canonical Wnt signalling Grocott, Timothy Johnson, Samuel Bailey, Andrew P. Streit, Andrea Article In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model system, that neural crest-derived transforming growth factor-βs activate both Smad3 and canonical Wnt signalling in the adjacent ectoderm to position the lens next to the retina. They do so by controlling Pax6 activity: although Smad3 may inhibit Pax6 protein function, its sustained downregulation requires transcriptional repression by Wnt-initiated β-catenin. We propose that the same neural crest-dependent signalling mechanism is used repeatedly to integrate different components of the eye and suggest a general role for the neural crest in coordinating central and peripheral parts of the sensory nervous system. Nature Publishing Group 2011-04 /pmc/articles/PMC3104559/ /pubmed/21468017 http://dx.doi.org/10.1038/ncomms1269 Text en Copyright © 2011, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Grocott, Timothy Johnson, Samuel Bailey, Andrew P. Streit, Andrea
spellingShingle	Grocott, Timothy Johnson, Samuel Bailey, Andrew P. Streit, Andrea Neural crest cells organize the eye via TGF-β and canonical Wnt signalling
author_facet	Grocott, Timothy Johnson, Samuel Bailey, Andrew P. Streit, Andrea
author_sort	Grocott, Timothy
title	Neural crest cells organize the eye via TGF-β and canonical Wnt signalling
title_short	Neural crest cells organize the eye via TGF-β and canonical Wnt signalling
title_full	Neural crest cells organize the eye via TGF-β and canonical Wnt signalling
title_fullStr	Neural crest cells organize the eye via TGF-β and canonical Wnt signalling
title_full_unstemmed	Neural crest cells organize the eye via TGF-β and canonical Wnt signalling
title_sort	neural crest cells organize the eye via tgf-β and canonical wnt signalling
description	In vertebrates, the lens and retina arise from different embryonic tissues raising the question of how they are aligned to form a functional eye. Neural crest cells are crucial for this process: in their absence, ectopic lenses develop far from the retina. Here we show, using the chick as a model system, that neural crest-derived transforming growth factor-βs activate both Smad3 and canonical Wnt signalling in the adjacent ectoderm to position the lens next to the retina. They do so by controlling Pax6 activity: although Smad3 may inhibit Pax6 protein function, its sustained downregulation requires transcriptional repression by Wnt-initiated β-catenin. We propose that the same neural crest-dependent signalling mechanism is used repeatedly to integrate different components of the eye and suggest a general role for the neural crest in coordinating central and peripheral parts of the sensory nervous system.
publisher	Nature Publishing Group
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104559/
_version_	1611456500070350848

Neural crest cells organize the eye via TGF-β and canonical Wnt signalling

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