Genomic DNA Pooling Strategy for Next-Generation Sequencing-Based Rare Variant Discovery in Abdominal Aortic Aneurysm Regions of Interest—Challenges and Limitations

Genomic DNA Pooling Strategy for Next-Generation Sequencing-Based Rare Variant Discovery in Abdominal Aortic Aneurysm Regions of Interest—Challenges and Limitations

The costs and efforts for sample preparation of hundreds of individuals, their genomic enrichment for regions of interest, and sufficient deep sequencing bring a significant burden to next-generation sequencing-based experiments. We investigated whether pooling of samples at the level of genomic DNA...

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Bibliographic Details
Main Authors: Harakalova, Magdalena, Nijman, Isaäc J., Medic, Jelena, Mokry, Michal, Renkens, Ivo, Blankensteijn, Jan D., Kloosterman, Wigard, Baas, Annette F., Cuppen, Edwin
Format: Online
Language:English
Published: Springer US 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099005/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099005/

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