Unfaithful Maintenance of Methylation Imprints Due to Loss of Maternal Nuclear Dnmt1 during Somatic Cell Nuclear Transfer

Unfaithful Maintenance of Methylation Imprints Due to Loss of Maternal Nuclear Dnmt1 during Somatic Cell Nuclear Transfer

The low success rate of somatic cell nuclear transfer (SCNT) in mammalian cloning is largely due to imprinting problems. However, little is known about the mechanisms of reprogramming imprinted genes during SCNT. Parental origin-specific DNA methylation regulates the monoallelic expression of imprin...

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Bibliographic Details
Main Authors: Wei, Yanchang, Huan, Yanjun, Shi, Yongqian, Liu, Zhongfeng, Bou, Gerelchimeg, Luo, Yibo, Zhang, Li, Yang, Cairong, Kong, Qingran, Tian, Jiangtian, Xia, Ping, Sun, Qing-Yuan, Liu, ZhongHua
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098883/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098883/

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