Site-Directed Mutagenesis of HIV-1 vpu Gene Demonstrates Two Clusters of Replication-Defective Mutants with Distinct Ability to Down-Modulate Cell Surface CD4 and Tetherin
HIV-1 Vpu acts positively on viral infectivity by mediating CD4 degradation in endoplasmic reticulum and enhances virion release by counteracting a virion release restriction factor, tetherin. In order to define the impact of Vpu activity on HIV-1 replication, we have generated a series of site-spec...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Frontiers Research Foundation
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095391/ |