Downregulation of FIP200 Induces Apoptosis of Glioblastoma Cells and Microvascular Endothelial Cells by Enhancing Pyk2 Activity

Downregulation of FIP200 Induces Apoptosis of Glioblastoma Cells and Microvascular Endothelial Cells by Enhancing Pyk2 Activity

The expression of focal adhesion kinase family interacting protein of 200-kDa (FIP200) in normal brain is limited to some neurons and glial cells. On immunohistochemical analysis of biopsies of glioblastoma tumors, we detected FIP200 in the tumor cells, tumor-associated endothelial cells, and occasi...

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Main Authors: Wang, Dongyan, Olman, Mitchell A., Stewart, Jerry, Tipps, Russell, Huang, Ping, Sanders, Paul W., Toline, Eric, Prayson, Richard A., Lee, Jeongwu, J.Weil, Robert, Palmer, Cheryl A., Gillespie, G. Yancey, Liu, Wei Michael, Pieper, Russell O., Guan, Jun-Lin, Gladson, Candece L.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094350/

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