Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome

The prevalence of hyperuricemia in obese children and adolescents and its association with metabolic syndrome are largely unknown. The objective of our study was to characterize hyperuricemia in relation to metabolic syndrome in Japanese children and adolescents with obesity. Between 2005 and 2008,...

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Main Authors:	Tang, Li, Kubota, Masaru, Nagai, Ayako, Mamemoto, Kimiyo, Tokuda, Masakuni
Format:	Online
Language:	English
Published:	PAGEPress Publications 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094014/

id	pubmed-3094014
recordtype	oai_dc
spelling	pubmed-30940142011-05-17 Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome Tang, Li Kubota, Masaru Nagai, Ayako Mamemoto, Kimiyo Tokuda, Masakuni Article The prevalence of hyperuricemia in obese children and adolescents and its association with metabolic syndrome are largely unknown. The objective of our study was to characterize hyperuricemia in relation to metabolic syndrome in Japanese children and adolescents with obesity. Between 2005 and 2008, we performed a cross-sectional study of 1,027 obese children and adolescents aged 6–14 years. Based on the reference value of serum uric acid we had established previously, hyperuricemia was defined as one standard deviation over the mean value at each age. The diagnosis of metabolic syndrome was made based on the Japanese criteria for children. A total of 213 children and adolescents (20.7%) was found to have hyperuricemia. The prevalence of hyperuricemia was significantly higher in the male gender and older age group. Sixty-five out of 213 subjects with hyperuricemia (30.5%) had metabolic syndrome, whereas 111 out of 814 subjects without hyperuricemia (13.6%) had metabolic syndrome. The most common abnormal component of metabolic syndrome was triglyceride, followed by diastolic blood pressure, systolic blood pressure, fasting blood glucose, and HDL-cholesterol. Such a tendency was almost identical between the two groups. We concluded that considering the association between hyperuricemia and metabolic syndrome in obese Japanese children and adolescents, the role of hyperuricemia in metabolic syndrome should receive more attention, beginning in early childhood. PAGEPress Publications 2010-06-18 /pmc/articles/PMC3094014/ /pubmed/21589837 http://dx.doi.org/10.4081/pr.2010.e12 Text en ©Copyright L. Tang et al., 2010 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Tang, Li Kubota, Masaru Nagai, Ayako Mamemoto, Kimiyo Tokuda, Masakuni
spellingShingle	Tang, Li Kubota, Masaru Nagai, Ayako Mamemoto, Kimiyo Tokuda, Masakuni Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
author_facet	Tang, Li Kubota, Masaru Nagai, Ayako Mamemoto, Kimiyo Tokuda, Masakuni
author_sort	Tang, Li
title	Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
title_short	Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
title_full	Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
title_fullStr	Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
title_full_unstemmed	Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
title_sort	hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome
description	The prevalence of hyperuricemia in obese children and adolescents and its association with metabolic syndrome are largely unknown. The objective of our study was to characterize hyperuricemia in relation to metabolic syndrome in Japanese children and adolescents with obesity. Between 2005 and 2008, we performed a cross-sectional study of 1,027 obese children and adolescents aged 6–14 years. Based on the reference value of serum uric acid we had established previously, hyperuricemia was defined as one standard deviation over the mean value at each age. The diagnosis of metabolic syndrome was made based on the Japanese criteria for children. A total of 213 children and adolescents (20.7%) was found to have hyperuricemia. The prevalence of hyperuricemia was significantly higher in the male gender and older age group. Sixty-five out of 213 subjects with hyperuricemia (30.5%) had metabolic syndrome, whereas 111 out of 814 subjects without hyperuricemia (13.6%) had metabolic syndrome. The most common abnormal component of metabolic syndrome was triglyceride, followed by diastolic blood pressure, systolic blood pressure, fasting blood glucose, and HDL-cholesterol. Such a tendency was almost identical between the two groups. We concluded that considering the association between hyperuricemia and metabolic syndrome in obese Japanese children and adolescents, the role of hyperuricemia in metabolic syndrome should receive more attention, beginning in early childhood.
publisher	PAGEPress Publications
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094014/
_version_	1611453619467452416

Hyperuricemia in obese children and adolescents: the relationship with metabolic syndrome

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