Altered mRNA Editing and Expression of Ionotropic Glutamate Receptors after Kainic Acid Exposure in Cyclooxygenase-2 Deficient Mice

Altered mRNA Editing and Expression of Ionotropic Glutamate Receptors after Kainic Acid Exposure in Cyclooxygenase-2 Deficient Mice

Kainic acid (KA) binds to the AMPA/KA receptors and induces seizures that result in inflammation, oxidative damage and neuronal death. We previously showed that cyclooxygenase-2 deficient (COX-2−/−) mice are more vulnerable to KA-induced excitotoxicity. Here, we investigated whether the increased su...

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Bibliographic Details
Main Authors: Caracciolo, Luca, Barbon, Alessandro, Palumbo, Sara, Mora, Cristina, Toscano, Christopher D., Bosetti, Francesca, Barlati, Sergio
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093380/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093380/

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