An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

Epithelial-mesenchymal transition is a form of cellular plasticity that is critical for embryonic development and tumor metastasis. This study shows that a signaling network involving autocrine TGF-β signaling, ZEB transcription factors, and the miR-200 family regulates interconversion between epith...

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Main Authors: Gregory, Philip A., Bracken, Cameron P., Smith, Eric, Bert, Andrew G., Wright, Josephine A., Roslan, Suraya, Morris, Melanie, Wyatt, Leila, Farshid, Gelareh, Lim, Yat-Yuen, Lindeman, Geoffrey J., Shannon, M. Frances, Drew, Paul A., Khew-Goodall, Yeesim, Goodall, Gregory J.
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093321/
id pubmed-3093321
recordtype oai_dc
spelling pubmed-30933212011-07-30 An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition Gregory, Philip A. Bracken, Cameron P. Smith, Eric Bert, Andrew G. Wright, Josephine A. Roslan, Suraya Morris, Melanie Wyatt, Leila Farshid, Gelareh Lim, Yat-Yuen Lindeman, Geoffrey J. Shannon, M. Frances Drew, Paul A. Khew-Goodall, Yeesim Goodall, Gregory J. Articles Epithelial-mesenchymal transition is a form of cellular plasticity that is critical for embryonic development and tumor metastasis. This study shows that a signaling network involving autocrine TGF-β signaling, ZEB transcription factors, and the miR-200 family regulates interconversion between epithelial and mesenchymal states. The American Society for Cell Biology 2011-05-15 /pmc/articles/PMC3093321/ /pubmed/21411626 http://dx.doi.org/10.1091/mbc.E11-02-0103 Text en © 2011 Gregory et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Gregory, Philip A.
Bracken, Cameron P.
Smith, Eric
Bert, Andrew G.
Wright, Josephine A.
Roslan, Suraya
Morris, Melanie
Wyatt, Leila
Farshid, Gelareh
Lim, Yat-Yuen
Lindeman, Geoffrey J.
Shannon, M. Frances
Drew, Paul A.
Khew-Goodall, Yeesim
Goodall, Gregory J.
spellingShingle Gregory, Philip A.
Bracken, Cameron P.
Smith, Eric
Bert, Andrew G.
Wright, Josephine A.
Roslan, Suraya
Morris, Melanie
Wyatt, Leila
Farshid, Gelareh
Lim, Yat-Yuen
Lindeman, Geoffrey J.
Shannon, M. Frances
Drew, Paul A.
Khew-Goodall, Yeesim
Goodall, Gregory J.
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
author_facet Gregory, Philip A.
Bracken, Cameron P.
Smith, Eric
Bert, Andrew G.
Wright, Josephine A.
Roslan, Suraya
Morris, Melanie
Wyatt, Leila
Farshid, Gelareh
Lim, Yat-Yuen
Lindeman, Geoffrey J.
Shannon, M. Frances
Drew, Paul A.
Khew-Goodall, Yeesim
Goodall, Gregory J.
author_sort Gregory, Philip A.
title An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
title_short An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
title_full An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
title_fullStr An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
title_full_unstemmed An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
title_sort autocrine tgf-β/zeb/mir-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
description Epithelial-mesenchymal transition is a form of cellular plasticity that is critical for embryonic development and tumor metastasis. This study shows that a signaling network involving autocrine TGF-β signaling, ZEB transcription factors, and the miR-200 family regulates interconversion between epithelial and mesenchymal states.
publisher The American Society for Cell Biology
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093321/
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