Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

Rett syndrome (RTT) is a neurodevelopmental autism spectrum disorder that affects girls due primarily to mutations in the gene encoding methyl-CpG binding protein 2 (MECP2). The majority of RTT patients carry missense and nonsense mutations leading to a hypomorphic MECP2, while null mutations leadin...

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Bibliographic Details
Main Authors: Cheung, Aaron Y.L., Horvath, Lindsay M., Grafodatskaya, Daria, Pasceri, Peter, Weksberg, Rosanna, Hotta, Akitsu, Carrel, Laura, Ellis, James
Format: Online
Language:English
Published: Oxford University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090191/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090191/

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