Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa

Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa

We explore the feasibility of using gold nanorods with efficient two-photon luminescence properties as contrast agents for intravital imaging of neoplasia. This investigation spanned ex vivo characterization in cells/tissue to in vivo implementation in an oral carcinogenesis model. GNRs were >40...

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Main Authors: Motamedi, Saam, Shilagard, Tuya, Edward, Kert, Koong, Luke, Qui, Suimin, Vargas, Gracie
Format: Online
Language:English
Published: Optical Society of America 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087576/
id pubmed-3087576
recordtype oai_dc
spelling pubmed-30875762011-05-10 Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa Motamedi, Saam Shilagard, Tuya Edward, Kert Koong, Luke Qui, Suimin Vargas, Gracie Nanotechnology and Plasmonics We explore the feasibility of using gold nanorods with efficient two-photon luminescence properties as contrast agents for intravital imaging of neoplasia. This investigation spanned ex vivo characterization in cells/tissue to in vivo implementation in an oral carcinogenesis model. GNRs were >40 times brighter than surrounding tissue. Intravital imaging revealed 3D microvasculature, and in dysplasia, abnormal vessels (dense and tortuous) compared to normal. GNRs were diffusely distributed in lesions after 24 hours. No known previous study has revealed abnormal vessel structure in dysplasia by imaging. Results suggest GNRs can function as high-contrast agents for in vivo visualization of carcinogenesis features. Optical Society of America 2011-04-13 /pmc/articles/PMC3087576/ /pubmed/21559131 http://dx.doi.org/10.1364/BOE.2.001194 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Motamedi, Saam
Shilagard, Tuya
Edward, Kert
Koong, Luke
Qui, Suimin
Vargas, Gracie
spellingShingle Motamedi, Saam
Shilagard, Tuya
Edward, Kert
Koong, Luke
Qui, Suimin
Vargas, Gracie
Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
author_facet Motamedi, Saam
Shilagard, Tuya
Edward, Kert
Koong, Luke
Qui, Suimin
Vargas, Gracie
author_sort Motamedi, Saam
title Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
title_short Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
title_full Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
title_fullStr Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
title_full_unstemmed Gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
title_sort gold nanorods for intravital vascular imaging of preneoplastic oral mucosa
description We explore the feasibility of using gold nanorods with efficient two-photon luminescence properties as contrast agents for intravital imaging of neoplasia. This investigation spanned ex vivo characterization in cells/tissue to in vivo implementation in an oral carcinogenesis model. GNRs were >40 times brighter than surrounding tissue. Intravital imaging revealed 3D microvasculature, and in dysplasia, abnormal vessels (dense and tortuous) compared to normal. GNRs were diffusely distributed in lesions after 24 hours. No known previous study has revealed abnormal vessel structure in dysplasia by imaging. Results suggest GNRs can function as high-contrast agents for in vivo visualization of carcinogenesis features.
publisher Optical Society of America
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087576/
_version_ 1611451799684775936

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