The Role of GSK3 in Presynaptic Function

The past ten years of research have identified a number of key roles for glycogen synthase kinase 3 (GSK3) at the synapse. In terms of presynaptic physiology, critical roles for GSK3 have been revealed in the growth and maturation of the nerve terminal and more recently a key role in the control of...

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Main Authors:	Smillie, Karen Janet, Cousin, Michael Alan
Format:	Online
Language:	English
Published:	SAGE-Hindawi Access to Research 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087464/

id	pubmed-3087464
recordtype	oai_dc
spelling	pubmed-30874642011-05-05 The Role of GSK3 in Presynaptic Function Smillie, Karen Janet Cousin, Michael Alan Review Article The past ten years of research have identified a number of key roles for glycogen synthase kinase 3 (GSK3) at the synapse. In terms of presynaptic physiology, critical roles for GSK3 have been revealed in the growth and maturation of the nerve terminal and more recently a key role in the control of activity-dependent bulk endocytosis of synaptic vesicles. This paper will summarise the major roles assigned to GSK3 in both immature and mature nerve terminals, the substrates GSK3 phosphorylates to exert its action, and how GSK3 activity is regulated by different presynaptic signalling cascades. The number of essential roles for GSK3, coupled with the numerous signalling cascades all converging to regulate its activity, suggests that GSK3 is a key integrator of multiple inputs to modulate the strength of neurotransmission. Modulation of these pathways may point to potential mechanisms to overcome synaptic failure in neurodegenerative disorders such as Alzheimer's disease. SAGE-Hindawi Access to Research 2011-03-14 /pmc/articles/PMC3087464/ /pubmed/21547219 http://dx.doi.org/10.4061/2011/263673 Text en Copyright © 2011 K. J. Smillie and M. A. Cousin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Smillie, Karen Janet Cousin, Michael Alan
spellingShingle	Smillie, Karen Janet Cousin, Michael Alan The Role of GSK3 in Presynaptic Function
author_facet	Smillie, Karen Janet Cousin, Michael Alan
author_sort	Smillie, Karen Janet
title	The Role of GSK3 in Presynaptic Function
title_short	The Role of GSK3 in Presynaptic Function
title_full	The Role of GSK3 in Presynaptic Function
title_fullStr	The Role of GSK3 in Presynaptic Function
title_full_unstemmed	The Role of GSK3 in Presynaptic Function
title_sort	role of gsk3 in presynaptic function
description	The past ten years of research have identified a number of key roles for glycogen synthase kinase 3 (GSK3) at the synapse. In terms of presynaptic physiology, critical roles for GSK3 have been revealed in the growth and maturation of the nerve terminal and more recently a key role in the control of activity-dependent bulk endocytosis of synaptic vesicles. This paper will summarise the major roles assigned to GSK3 in both immature and mature nerve terminals, the substrates GSK3 phosphorylates to exert its action, and how GSK3 activity is regulated by different presynaptic signalling cascades. The number of essential roles for GSK3, coupled with the numerous signalling cascades all converging to regulate its activity, suggests that GSK3 is a key integrator of multiple inputs to modulate the strength of neurotransmission. Modulation of these pathways may point to potential mechanisms to overcome synaptic failure in neurodegenerative disorders such as Alzheimer's disease.
publisher	SAGE-Hindawi Access to Research
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087464/
_version_	1611451755644583936

The Role of GSK3 in Presynaptic Function

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