Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease

Obesity is associated with insulin resistance, hypertension, and cardiovascular disease, but the mechanisms underlying these associations are incompletely understood. Microvascular dysfunction may play an important role in the pathogenesis of both insulin resistance and hypertension in obesity. Adip...

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Main Authors:	Meijer, Rick I., Serne, Erik H., Smulders, Yvo M., van Hinsbergh, Victor W. M., Yudkin, John S., Eringa, Etto C.
Format:	Online
Language:	English
Published:	Current Science Inc. 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085790/

id	pubmed-3085790
recordtype	oai_dc
spelling	pubmed-30857902011-06-06 Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease Meijer, Rick I. Serne, Erik H. Smulders, Yvo M. van Hinsbergh, Victor W. M. Yudkin, John S. Eringa, Etto C. Article Obesity is associated with insulin resistance, hypertension, and cardiovascular disease, but the mechanisms underlying these associations are incompletely understood. Microvascular dysfunction may play an important role in the pathogenesis of both insulin resistance and hypertension in obesity. Adipose tissue-derived substances (adipokines) and especially inflammatory products of adipose tissue control insulin sensitivity and vascular function. In the past years, adipose tissue associated with the vasculature, or perivascular adipose tissue (PAT), has been shown to produce a variety of adipokines that contribute to regulation of vascular tone and local inflammation. This review describes our current understanding of the mechanisms linking perivascular adipose tissue to vascular function, inflammation, and insulin resistance. Furthermore, we will discuss mechanisms controlling the quantity and adipokines secretion by PAT. Current Science Inc. 2011-04-05 2011-06 /pmc/articles/PMC3085790/ /pubmed/21461998 http://dx.doi.org/10.1007/s11892-011-0186-y Text en © The Author(s) 2011
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Meijer, Rick I. Serne, Erik H. Smulders, Yvo M. van Hinsbergh, Victor W. M. Yudkin, John S. Eringa, Etto C.
spellingShingle	Meijer, Rick I. Serne, Erik H. Smulders, Yvo M. van Hinsbergh, Victor W. M. Yudkin, John S. Eringa, Etto C. Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
author_facet	Meijer, Rick I. Serne, Erik H. Smulders, Yvo M. van Hinsbergh, Victor W. M. Yudkin, John S. Eringa, Etto C.
author_sort	Meijer, Rick I.
title	Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
title_short	Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
title_full	Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
title_fullStr	Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
title_full_unstemmed	Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease
title_sort	perivascular adipose tissue and its role in type 2 diabetes and cardiovascular disease
description	Obesity is associated with insulin resistance, hypertension, and cardiovascular disease, but the mechanisms underlying these associations are incompletely understood. Microvascular dysfunction may play an important role in the pathogenesis of both insulin resistance and hypertension in obesity. Adipose tissue-derived substances (adipokines) and especially inflammatory products of adipose tissue control insulin sensitivity and vascular function. In the past years, adipose tissue associated with the vasculature, or perivascular adipose tissue (PAT), has been shown to produce a variety of adipokines that contribute to regulation of vascular tone and local inflammation. This review describes our current understanding of the mechanisms linking perivascular adipose tissue to vascular function, inflammation, and insulin resistance. Furthermore, we will discuss mechanisms controlling the quantity and adipokines secretion by PAT.
publisher	Current Science Inc.
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085790/
_version_	1611451435664277504

Perivascular Adipose Tissue and Its Role in Type 2 Diabetes and Cardiovascular Disease

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