Immunological and Clinical Effects of Vaccines Targeting p53-Overexpressing Malignancies
Approximately 50% of human malignancies carry p53 mutations, which makes it a potential antigenic target for cancer immunotherapy. Adoptive transfer with p53-specific cytotoxic T-lymphocytes (CTL) and CD4+ T-helper cells eradicates p53-overexpressing tumors in mice. Furthermore, p53 antibodies and p...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085500/ |