Structural Determination of Three Different Series of Compounds as Hsp90 Inhibitors Using 3D-QSAR Modeling, Molecular Docking and Molecular Dynamics Methods

Structural Determination of Three Different Series of Compounds as Hsp90 Inhibitors Using 3D-QSAR Modeling, Molecular Docking and Molecular Dynamics Methods

Hsp90 is involved in correcting, folding, maturation and activation of a diverse array of client proteins; it has also been implicated in the treatment of cancer in recent years. In this work, comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), m...

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Bibliographic Details
Main Authors: Liu, Jianling, Wang, Fangfang, Ma, Zhi, Wang, Xia, Wang, Yonghua
Format: Online
Language:English
Published: Molecular Diversity Preservation International (MDPI) 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083683/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083683/

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