Primary hepatocytes as targets for Hepatitis C virus replication

Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of...

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Main Authors:	Farquhar, M J, McKeating, J A
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2008
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083516/

id	pubmed-3083516
recordtype	oai_dc
spelling	pubmed-30835162011-05-05 Primary hepatocytes as targets for Hepatitis C virus replication Farquhar, M J McKeating, J A Review Article Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry. Blackwell Publishing Ltd 2008-12 /pmc/articles/PMC3083516/ /pubmed/19087224 http://dx.doi.org/10.1111/j.1365-2893.2008.01051.x Text en Journal compilation © 2008 Blackwell Publishing Ltd http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Farquhar, M J McKeating, J A
spellingShingle	Farquhar, M J McKeating, J A Primary hepatocytes as targets for Hepatitis C virus replication
author_facet	Farquhar, M J McKeating, J A
author_sort	Farquhar, M J
title	Primary hepatocytes as targets for Hepatitis C virus replication
title_short	Primary hepatocytes as targets for Hepatitis C virus replication
title_full	Primary hepatocytes as targets for Hepatitis C virus replication
title_fullStr	Primary hepatocytes as targets for Hepatitis C virus replication
title_full_unstemmed	Primary hepatocytes as targets for Hepatitis C virus replication
title_sort	primary hepatocytes as targets for hepatitis c virus replication
description	Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.
publisher	Blackwell Publishing Ltd
publishDate	2008
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083516/
_version_	1611450770819907584

Primary hepatocytes as targets for Hepatitis C virus replication

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