Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease

Huntington's disease (HD) is caused by an expanded CAG tract in the Interesting transcript 15 (IT15) gene encoding the 350 kDa huntingtin protein. Cellular stresses can trigger the release of huntingtin from the endoplasmic reticulum, allowing huntingtin nuclear entry. Here, we show that endoge...

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Bibliographic Details
Main Authors: Munsie, Lise, Caron, Nicholas, Atwal, Randy Singh, Marsden, Ian, Wild, Edward J., Bamburg, James R., Tabrizi, Sarah J., Truant, Ray
Format: Online
Language:English
Published: Oxford University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080606/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080606/

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