The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance i...
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Korean Diabetes Association
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080574/ |
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pubmed-30805742011-05-02 The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus Park, Kyong Soo Sulwon Lecture 2009 Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance in genome-wide association studies have greatly improved our understanding of the pathophysiology of T2DM. As of the end of 2010, there are more than 40 confirmed T2DM-associated genetic loci. Most of the T2DM susceptibility genes were implicated in decreased β-cell function. However, these genetic variations have a modest effect and their combination only explains less than 10% of the T2DM heritability. With the advent of the next-generation sequencing technology, we will soon identify rare variants of larger effect as well as causal variants. These advances in understanding the genetics of T2DM will lead to the development of new therapeutic and preventive strategies and individualized medicine. Korean Diabetes Association 2011-02 2011-02-28 /pmc/articles/PMC3080574/ /pubmed/21537408 http://dx.doi.org/10.4093/dmj.2011.35.1.12 Text en Copyright © 2011 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Park, Kyong Soo |
| spellingShingle |
Park, Kyong Soo The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| author_facet |
Park, Kyong Soo |
| author_sort |
Park, Kyong Soo |
| title |
The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_short |
The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_full |
The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_fullStr |
The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_full_unstemmed |
The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus |
| title_sort |
search for genetic risk factors of type 2 diabetes mellitus |
| description |
Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance in genome-wide association studies have greatly improved our understanding of the pathophysiology of T2DM. As of the end of 2010, there are more than 40 confirmed T2DM-associated genetic loci. Most of the T2DM susceptibility genes were implicated in decreased β-cell function. However, these genetic variations have a modest effect and their combination only explains less than 10% of the T2DM heritability. With the advent of the next-generation sequencing technology, we will soon identify rare variants of larger effect as well as causal variants. These advances in understanding the genetics of T2DM will lead to the development of new therapeutic and preventive strategies and individualized medicine. |
| publisher |
Korean Diabetes Association |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080574/ |
| _version_ |
1611450057527132160 |