Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes

The proinflammatory cytokine TNFα fails to provoke cell death in isolated hepatocytes but has been implicated in hepatocyte apoptosis during liver diseases associated with chronic inflammation. Recently, we showed that TNFα is able to sensitize primary murine hepatocytes cultured on collagen to Fas...

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Bibliographic Details
Main Authors: Schlatter, Rebekka, Schmich, Kathrin, Lutz, Anna, Trefzger, Judith, Sawodny, Oliver, Ederer, Michael, Merfort, Irmgard
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080376/