Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms

Dehydroepiandrosterone sulphate (DHEAS) is the most abundant circulating steroid secreted by adrenal glands—yet its function is unknown. Its serum concentration declines significantly with increasing age, which has led to speculation that a relative DHEAS deficiency may contribute to the development...

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Main Authors: Zhai, Guangju, Teumer, Alexander, Stolk, Lisette, Perry, John R. B., Vandenput, Liesbeth, Coviello, Andrea D., Koster, Annemarie, Bell, Jordana T., Bhasin, Shalender, Eriksson, Joel, Eriksson, Anna, Ernst, Florian, Ferrucci, Luigi, Frayling, Timothy M., Glass, Daniel, Grundberg, Elin, Haring, Robin, Hedman, Åsa K., Hofman, Albert, Kiel, Douglas P., Kroemer, Heyo K., Liu, Yongmei, Lunetta, Kathryn L., Maggio, Marcello, Lorentzon, Mattias, Mangino, Massimo, Melzer, David, Miljkovic, Iva, Nica, Alexandra, Penninx, Brenda W. J. H., Vasan, Ramachandran S., Rivadeneira, Fernando, Small, Kerrin S., Soranzo, Nicole, Uitterlinden, André G., Völzke, Henry, Wilson, Scott G., Xi, Li, Zhuang, Wei Vivian, Harris, Tamara B., Murabito, Joanne M., Ohlsson, Claes, Murray, Anna, de Jong, Frank H., Spector, Tim D., Wallaschofski, Henri
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077384/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077384/

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