Deubiquitinase HAUSP Stabilizes REST and Promotes Maintenance of Neural Progenitor Cells
The repressor element 1-silencing transcription factor (REST) functions as a master regulator to maintain neural stem/progenitor cells (NPCs). REST undergoes proteasomal degradation through β-TrCP-mediated ubiquitination during neuronal differentiation. However, reciprocal mechanisms that stabilize...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076066/ |