Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments

An association panel consisting of 185 accessions representative of the barley germplasm cultivated in the Mediterranean basin was used to localise quantitative trait loci (QTL) controlling grain yield and yield related traits. The germplasm set was genotyped with 1,536 SNP markers and tested for as...

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Main Authors:	Comadran, J., Russell, J. R., Booth, A., Pswarayi, A., Ceccarelli, S., Grando, S., Stanca, A. M., Pecchioni, N., Akar, T., Al-Yassin, A., Benbelkacem, A., Ouabbou, H., Bort, J., van Eeuwijk, F. A., Thomas, W. T. B., Romagosa, I.
Format:	Online
Language:	English
Published:	Springer-Verlag 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075395/

id	pubmed-3075395
recordtype	oai_dc
spelling	pubmed-30753952011-05-23 Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments Comadran, J. Russell, J. R. Booth, A. Pswarayi, A. Ceccarelli, S. Grando, S. Stanca, A. M. Pecchioni, N. Akar, T. Al-Yassin, A. Benbelkacem, A. Ouabbou, H. Bort, J. van Eeuwijk, F. A. Thomas, W. T. B. Romagosa, I. Original Paper An association panel consisting of 185 accessions representative of the barley germplasm cultivated in the Mediterranean basin was used to localise quantitative trait loci (QTL) controlling grain yield and yield related traits. The germplasm set was genotyped with 1,536 SNP markers and tested for associations with phenotypic data gathered over 2 years for a total of 24 year × location combinations under a broad range of environmental conditions. Analysis of multi-environmental trial (MET) data by fitting a mixed model with kinship estimates detected from two to seven QTL for the major components of yield including 1000 kernel weight, grains per spike and spikes per m2, as well as heading date, harvest index and plant height. Several of the associations involved SNPs tightly linked to known major genes determining spike morphology in barley (vrs1 and int-c). Similarly, the largest QTL for heading date co-locates with SNPs linked with eam6, a major locus for heading date in barley for autumn sown conditions. Co-localization of several QTL related to yield components traits suggest that major developmental loci may be linked to most of the associations. This study highlights the potential of association genetics to identify genetic variants controlling complex traits. Springer-Verlag 2011-01-30 2011-05 /pmc/articles/PMC3075395/ /pubmed/21279625 http://dx.doi.org/10.1007/s00122-011-1537-4 Text en © The Author(s) 2011
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Comadran, J. Russell, J. R. Booth, A. Pswarayi, A. Ceccarelli, S. Grando, S. Stanca, A. M. Pecchioni, N. Akar, T. Al-Yassin, A. Benbelkacem, A. Ouabbou, H. Bort, J. van Eeuwijk, F. A. Thomas, W. T. B. Romagosa, I.
spellingShingle	Comadran, J. Russell, J. R. Booth, A. Pswarayi, A. Ceccarelli, S. Grando, S. Stanca, A. M. Pecchioni, N. Akar, T. Al-Yassin, A. Benbelkacem, A. Ouabbou, H. Bort, J. van Eeuwijk, F. A. Thomas, W. T. B. Romagosa, I. Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments
author_facet	Comadran, J. Russell, J. R. Booth, A. Pswarayi, A. Ceccarelli, S. Grando, S. Stanca, A. M. Pecchioni, N. Akar, T. Al-Yassin, A. Benbelkacem, A. Ouabbou, H. Bort, J. van Eeuwijk, F. A. Thomas, W. T. B. Romagosa, I.
author_sort	Comadran, J.
title	Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments
title_short	Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments
title_full	Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments
title_fullStr	Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments
title_full_unstemmed	Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments
title_sort	mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in hordeum vulgare in mediterranean environments
description	An association panel consisting of 185 accessions representative of the barley germplasm cultivated in the Mediterranean basin was used to localise quantitative trait loci (QTL) controlling grain yield and yield related traits. The germplasm set was genotyped with 1,536 SNP markers and tested for associations with phenotypic data gathered over 2 years for a total of 24 year × location combinations under a broad range of environmental conditions. Analysis of multi-environmental trial (MET) data by fitting a mixed model with kinship estimates detected from two to seven QTL for the major components of yield including 1000 kernel weight, grains per spike and spikes per m2, as well as heading date, harvest index and plant height. Several of the associations involved SNPs tightly linked to known major genes determining spike morphology in barley (vrs1 and int-c). Similarly, the largest QTL for heading date co-locates with SNPs linked with eam6, a major locus for heading date in barley for autumn sown conditions. Co-localization of several QTL related to yield components traits suggest that major developmental loci may be linked to most of the associations. This study highlights the potential of association genetics to identify genetic variants controlling complex traits.
publisher	Springer-Verlag
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075395/
_version_	1611449188223025152

Mixed model association scans of multi-environmental trial data reveal major loci controlling yield and yield related traits in Hordeum vulgare in Mediterranean environments

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