Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy
In areas where parasitic worm infections have been successfully reduced as a result of deworming campaigns, the level of infections and drug efficacy must be carefully monitored. For this purpose, diagnostic methods with a high sensitivity are needed. We compared the accuracy of the widely used Kato...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075226/ |
| id |
pubmed-3075226 |
|---|---|
| recordtype |
oai_dc |
| spelling |
pubmed-30752262011-04-29 Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy Knopp, Stefanie Speich, Benjamin Hattendorf, Jan Rinaldi, Laura Mohammed, Khalfan A. Khamis, I. Simba Mohammed, Alisa S. Albonico, Marco Rollinson, David Marti, Hanspeter Cringoli, Giuseppe Utzinger, Jürg Research Article In areas where parasitic worm infections have been successfully reduced as a result of deworming campaigns, the level of infections and drug efficacy must be carefully monitored. For this purpose, diagnostic methods with a high sensitivity are needed. We compared the accuracy of the widely used Kato-Katz method with the more recently developed FLOTAC technique for the diagnosis of parasitic worms. Our study was done with children on Zanzibar island, Tanzania, within the frame of an anthelmintic drug efficacy study. We collected stool samples from 343 children in two primary schools before and after treatment and examined the stool samples with both methods. FLOTAC showed a higher sensitivity than Kato-Katz for the diagnosis of roundworm and whipworm, but a lower sensitivity for hookworm diagnosis. The cure rates determined by FLOTAC were lower for roundworm and whipworm when compared with Kato-Katz. The opposite was found for hookworm. Egg reduction rates were generally lower when the FLOTAC technique was used. Our results suggest that the FLOTAC method, after additional optimization, can become a viable alternative to the Kato-Katz method for anthelmintic drug efficacy studies and for monitoring and evaluation of deworming programs. Public Library of Science 2011-04-12 /pmc/articles/PMC3075226/ /pubmed/21532740 http://dx.doi.org/10.1371/journal.pntd.0001036 Text en Knopp et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Knopp, Stefanie Speich, Benjamin Hattendorf, Jan Rinaldi, Laura Mohammed, Khalfan A. Khamis, I. Simba Mohammed, Alisa S. Albonico, Marco Rollinson, David Marti, Hanspeter Cringoli, Giuseppe Utzinger, Jürg |
| spellingShingle |
Knopp, Stefanie Speich, Benjamin Hattendorf, Jan Rinaldi, Laura Mohammed, Khalfan A. Khamis, I. Simba Mohammed, Alisa S. Albonico, Marco Rollinson, David Marti, Hanspeter Cringoli, Giuseppe Utzinger, Jürg Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy |
| author_facet |
Knopp, Stefanie Speich, Benjamin Hattendorf, Jan Rinaldi, Laura Mohammed, Khalfan A. Khamis, I. Simba Mohammed, Alisa S. Albonico, Marco Rollinson, David Marti, Hanspeter Cringoli, Giuseppe Utzinger, Jürg |
| author_sort |
Knopp, Stefanie |
| title |
Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy |
| title_short |
Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy |
| title_full |
Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy |
| title_fullStr |
Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy |
| title_full_unstemmed |
Diagnostic Accuracy of Kato-Katz and FLOTAC for Assessing Anthelmintic Drug Efficacy |
| title_sort |
diagnostic accuracy of kato-katz and flotac for assessing anthelmintic drug efficacy |
| description |
In areas where parasitic worm infections have been successfully reduced as a result of deworming campaigns, the level of infections and drug efficacy must be carefully monitored. For this purpose, diagnostic methods with a high sensitivity are needed. We compared the accuracy of the widely used Kato-Katz method with the more recently developed FLOTAC technique for the diagnosis of parasitic worms. Our study was done with children on Zanzibar island, Tanzania, within the frame of an anthelmintic drug efficacy study. We collected stool samples from 343 children in two primary schools before and after treatment and examined the stool samples with both methods. FLOTAC showed a higher sensitivity than Kato-Katz for the diagnosis of roundworm and whipworm, but a lower sensitivity for hookworm diagnosis. The cure rates determined by FLOTAC were lower for roundworm and whipworm when compared with Kato-Katz. The opposite was found for hookworm. Egg reduction rates were generally lower when the FLOTAC technique was used. Our results suggest that the FLOTAC method, after additional optimization, can become a viable alternative to the Kato-Katz method for anthelmintic drug efficacy studies and for monitoring and evaluation of deworming programs. |
| publisher |
Public Library of Science |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075226/ |
| _version_ |
1611449156781473792 |