Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates

Kindlin proteins represent a newly discovered family of evolutionarily conserved FERM domain-containing proteins. This family includes three highly conserved proteins: Kindlin-1, Kindlin-2 and Kindlin-3. All three Kindlin proteins are associated with focal adhesions and are involved in integrin acti...

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Bibliographic Details
Main Authors: Khan, Ammad Aslam, Janke, Axel, Shimokawa, Takashi, Zhang, Hongquan
Format: Online
Language:English
Published: Libertas Academica 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072626/