Evidence for an association between migraine and the hypocretin receptor 1 gene

The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case–control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypi...

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Main Authors:	Rainero, Innocenzo, Rubino, Elisa, Gallone, Salvatore, Fenoglio, Pierpaola, Picci, Luigi Rocco, Giobbe, Laura, Ostacoli, Luca, Pinessi, Lorenzo
Format:	Online
Language:	English
Published:	Springer Milan 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072499/

id	pubmed-3072499
recordtype	oai_dc
spelling	pubmed-30724992011-05-18 Evidence for an association between migraine and the hypocretin receptor 1 gene Rainero, Innocenzo Rubino, Elisa Gallone, Salvatore Fenoglio, Pierpaola Picci, Luigi Rocco Giobbe, Laura Ostacoli, Luca Pinessi, Lorenzo Original The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case–control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypic and allelic frequencies of the rs2271933 non-synonymous polymorphism resulted different (χ2 = 9.872, p = 0.007; χ2 = 8.108, p = 0.004) between migraineurs and controls. The carriage of the A allele was associated with an increased migraine risk (OR 1.42, 95% CI 1.11–1.81). When we divided the migraine patients into different subgroups, the difference reached the level of statistical significance only in migraine without aura. The different genotypes had no significant effect on the examined clinical characteristics of the disease. In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine. Springer Milan 2011-02-23 2011-04 /pmc/articles/PMC3072499/ /pubmed/21344296 http://dx.doi.org/10.1007/s10194-011-0314-8 Text en © The Author(s) 2011
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Rainero, Innocenzo Rubino, Elisa Gallone, Salvatore Fenoglio, Pierpaola Picci, Luigi Rocco Giobbe, Laura Ostacoli, Luca Pinessi, Lorenzo
spellingShingle	Rainero, Innocenzo Rubino, Elisa Gallone, Salvatore Fenoglio, Pierpaola Picci, Luigi Rocco Giobbe, Laura Ostacoli, Luca Pinessi, Lorenzo Evidence for an association between migraine and the hypocretin receptor 1 gene
author_facet	Rainero, Innocenzo Rubino, Elisa Gallone, Salvatore Fenoglio, Pierpaola Picci, Luigi Rocco Giobbe, Laura Ostacoli, Luca Pinessi, Lorenzo
author_sort	Rainero, Innocenzo
title	Evidence for an association between migraine and the hypocretin receptor 1 gene
title_short	Evidence for an association between migraine and the hypocretin receptor 1 gene
title_full	Evidence for an association between migraine and the hypocretin receptor 1 gene
title_fullStr	Evidence for an association between migraine and the hypocretin receptor 1 gene
title_full_unstemmed	Evidence for an association between migraine and the hypocretin receptor 1 gene
title_sort	evidence for an association between migraine and the hypocretin receptor 1 gene
description	The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case–control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypic and allelic frequencies of the rs2271933 non-synonymous polymorphism resulted different (χ2 = 9.872, p = 0.007; χ2 = 8.108, p = 0.004) between migraineurs and controls. The carriage of the A allele was associated with an increased migraine risk (OR 1.42, 95% CI 1.11–1.81). When we divided the migraine patients into different subgroups, the difference reached the level of statistical significance only in migraine without aura. The different genotypes had no significant effect on the examined clinical characteristics of the disease. In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine.
publisher	Springer Milan
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072499/
_version_	1611448693346533376

Evidence for an association between migraine and the hypocretin receptor 1 gene

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