Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants

Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance i...

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Main Authors:	Kobbe, Robin, Hogan, Benedikt, Adjei, Samuel, Klein, Philipp, Kreuels, Benno, Loag, Wibke, Adjei, Ohene, May, Jürgen
Format:	Online
Language:	English
Published:	Oxford University Press 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071230/

id	pubmed-3071230
recordtype	oai_dc
spelling	pubmed-30712302011-04-05 Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants Kobbe, Robin Hogan, Benedikt Adjei, Samuel Klein, Philipp Kreuels, Benno Loag, Wibke Adjei, Ohene May, Jürgen Major Articles and Brief Reports Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti–Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi. Oxford University Press 2011-02-15 2010-12-20 /pmc/articles/PMC3071230/ /pubmed/21248056 http://dx.doi.org/10.1093/infdis/jiq079 Text en © The Author 2011. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kobbe, Robin Hogan, Benedikt Adjei, Samuel Klein, Philipp Kreuels, Benno Loag, Wibke Adjei, Ohene May, Jürgen
spellingShingle	Kobbe, Robin Hogan, Benedikt Adjei, Samuel Klein, Philipp Kreuels, Benno Loag, Wibke Adjei, Ohene May, Jürgen Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants
author_facet	Kobbe, Robin Hogan, Benedikt Adjei, Samuel Klein, Philipp Kreuels, Benno Loag, Wibke Adjei, Ohene May, Jürgen
author_sort	Kobbe, Robin
title	Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants
title_short	Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants
title_full	Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants
title_fullStr	Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants
title_full_unstemmed	Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants
title_sort	follow-up survey of children who received sulfadoxine-pyrimethamine for intermittent preventive antimalarial treatment in infants
description	Recently, the World Health Organization emphasized the potential benefit of intermittent preventive treatment in infants (IPTi) to control malaria and officially recommended implementation of IPTi with sulfadoxine-pyrimethamine (SP) in areas with moderate and high transmission, where SP resistance is not high. As reported rebound effects make further observation mandatory, we performed a survey of participants of a former IPTi trial. Malariometric parameters were similar in the SP and the placebo group. In contrast, anti–Plasmodium falciparum lysate immunoglobulin G antibody levels, a proxy measure for preceding malaria episodes, remained lower in the SP arm. The most likely explanation is a lower overall exposure to parasitic antigens after IPTi.
publisher	Oxford University Press
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071230/
_version_	1611448359473643520

Follow-up Survey of Children Who Received Sulfadoxine-Pyrimethamine for Intermittent Preventive Antimalarial Treatment in Infants

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