Physical disruption of skin during poxvirus immunization is critical for the generation of highly protective T cell-mediated immunity
Variola major infection (Smallpox) claimed hundreds of millions lives before it was eradicated by a simple vaccination strategy: epicutaneous application of the related orthopoxvirus Vaccinia virus (VACV) to superficially injured skin (skin scarification, s.s.)1. However, the remarkable success of t...
| Main Authors: | , , , , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
2010
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070948/ |