Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression
We examined the stage specificity and heterogeneity of 18p11 alterations in a series of tumors representing 96 microdissected samples. Significant loss of heterozygosity (LOH) (63%) was found, with 56% occurring early in ductal carcinoma in situ. Although most cases indicated LOH was clonally inheri...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
BioMed Central
2001
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC30703/ |