An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV

An Anti-HIV-1 V3 Loop Antibody Fully Protects Cross-Clade and Elicits T-Cell Immunity in Macaques Mucosally Challenged with an R5 Clade C SHIV

Neutralizing antibodies have been shown to protect macaques against SHIV challenge. However, genetically diverse HIV-1 clades have evolved, and a key question left unanswered is whether neutralizing antibodies can confer cross-clade protection in vivo. The novel human monoclonal antibody HGN194 was...

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Bibliographic Details
Main Authors: Watkins, Jennifer D., Siddappa, Nagadenahalli B., Lakhashe, Samir K., Humbert, Michael, Sholukh, Anton, Hemashettar, Girish, Wong, Yin Ling, Yoon, John K., Wang, Wendy, Novembre, Francis J., Villinger, Francois, Ibegbu, Chris, Patel, Kalpana, Corti, Davide, Agatic, Gloria, Vanzetta, Fabrizia, Bianchi, Siro, Heeney, Jonathan L., Sallusto, Federica, Lanzavecchia, Antonio, Ruprecht, Ruth M.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069056/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069056/

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