Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene

Predicting Phenotypic Severity of Uncertain Gene Variants in the RET Proto-Oncogene

Although reported gene variants in the RET oncogene have been directly associated with multiple endocrine neoplasia type 2 and hereditary medullary thyroid carcinoma, other mutations are classified as variants of uncertain significance (VUS) until the associated clinical phenotype is made clear. Cur...

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Bibliographic Details
Main Authors: Crockett, David K., Piccolo, Stephen R., Ridge, Perry G., Margraf, Rebecca L., Lyon, Elaine, Williams, Marc S., Mitchell, Joyce A.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068179/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068179/

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