Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences

Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against HIV-1-B Nef by Inclusion of Epitope Variant Sequences

Different vaccine approaches cope with HIV-1 diversity, ranging from centralized1–4 to variability-encompassing5–7 antigens. For all these strategies, a concern remains: how does HIV-1 diversity impact epitope recognition by the immune system? We studied the relationship between HIV-1 diversity and...

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Bibliographic Details
Main Authors: Rolland, Morgane, Frahm, Nicole, Nickle, David C., Jojic, Nebojsa, Deng, Wenjie, Allen, Todd M., Brander, Christian, Heckerman, David E., Mullins, James I.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065451/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065451/

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