Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

Glomerular filtration rate (GFR) was evaluated in 32 Wilms’ tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and...

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Main Authors:	Stefanowicz, Joanna, Kosiak, Mateusz, Romanowicz, Grzegorz, Owczuk, Radosław, Adamkiewicz-Drożyńska, Elżbieta, Balcerska, Anna
Format:	Online
Language:	English
Published:	Springer-Verlag 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062777/

id	pubmed-3062777
recordtype	oai_dc
spelling	pubmed-30627772011-04-05 Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors Stefanowicz, Joanna Kosiak, Mateusz Romanowicz, Grzegorz Owczuk, Radosław Adamkiewicz-Drożyńska, Elżbieta Balcerska, Anna Original Article Glomerular filtration rate (GFR) was evaluated in 32 Wilms’ tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m2 [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m2 [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m2 with 99 Tc- DTPA. Springer-Verlag 2011-01-29 2011-05 /pmc/articles/PMC3062777/ /pubmed/21279390 http://dx.doi.org/10.1007/s00467-011-1759-3 Text en © The Author(s) 2011
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Stefanowicz, Joanna Kosiak, Mateusz Romanowicz, Grzegorz Owczuk, Radosław Adamkiewicz-Drożyńska, Elżbieta Balcerska, Anna
spellingShingle	Stefanowicz, Joanna Kosiak, Mateusz Romanowicz, Grzegorz Owczuk, Radosław Adamkiewicz-Drożyńska, Elżbieta Balcerska, Anna Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
author_facet	Stefanowicz, Joanna Kosiak, Mateusz Romanowicz, Grzegorz Owczuk, Radosław Adamkiewicz-Drożyńska, Elżbieta Balcerska, Anna
author_sort	Stefanowicz, Joanna
title	Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
title_short	Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
title_full	Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
title_fullStr	Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
title_full_unstemmed	Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors
title_sort	glomerular filtration rate and prevalence of chronic kidney disease in wilms’ tumour survivors
description	Glomerular filtration rate (GFR) was evaluated in 32 Wilms’ tumour survivors (WTs) in a cross-sectional study using 99 Tc-diethylene triamine pentaacetic acid (99 Tc-DTPA) clearance, the Schwartz formula, the new Schwartz equation for chronic kidney disease (CKD), cystatin C serum concentration and the Filler formula. Kidney damage was established by beta-2-microglobulin (B-2-M) and albumin urine excretion, urine sediment and ultrasound examination. Blood pressure was measured. No differences were found between the mean GFR in 99 Tc-DTPA and the new Schwartz equation for CKD (91.8 ± 11.3 vs. 94.3 ± 10.2 ml/min/1.73 m2 [p = 0.55] respectively). No differences were observed between estimated glomerular filtration rate (eGFR) using the Schwartz formula and the Filler formula either (122.3 ± 19.9 vs. 129.8 ± 23.9 ml/min/1.73 m2 [p = 0.28] respectively). Increased urine albumin and B-2-M excretion, which are signs of kidney damage, were found in 7 (22%) and 3 (9.4%) WTs respectively. Ultrasound signs of kidney damage were found in 14 patients (43%). Five patients (15.6%) had more than one sign of kidney damage. Eighteen individuals (56.25%) had CKD stage I (10 with signs of kidney damage; 8 without). Fourteen individuals (43.75%) had CKD stage II (6 with signs of kidney damage; 8 without). The new Schwartz equation for CKD better estimated GFR in comparison to the Schwartz formula and the Filler formula. Furthermore, the WT survivors had signs of kidney damage despite the fact that GFR was not decreased below 90 ml/min/1.73 m2 with 99 Tc- DTPA.
publisher	Springer-Verlag
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3062777/
_version_	1611446651278327808

Glomerular filtration rate and prevalence of chronic kidney disease in Wilms’ tumour survivors

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