Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress

► Nrf2 anti-oxidant function is impaired when HDAC activity is inhibited. ► HDAC inhibition decreases Nrf2 protein stability. ► HDAC2 is involved in reduced Nrf2 stability and both correlate in COPD samples. ► HDAC inhibition increases Nrf2 acetylation.

Bibliographic Details
Main Authors: Mercado, Nicolas, Thimmulappa, Rajesh, Thomas, Catherine M.R., Fenwick, Peter S., Chana, Kirandeep K., Donnelly, Louise E., Biswal, Shyam, Ito, Kazuhiro, Barnes, Peter J.
Format: Online
Language:English
Published: Academic Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061319/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061319/

Similar Items