The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus

Synaptic plasticity has historically been investigated most intensely in the hippocampus and therefore it is somewhat surprising that the majority of studies on spike timing-dependent plasticity (STDP) have focused not in the hippocampus but on synapses in the cortex. One of the major reasons for th...

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Main Authors:	Buchanan, Katherine A., Mellor, Jack R.
Format:	Online
Language:	English
Published:	Frontiers Research Foundation 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059701/

id	pubmed-3059701
recordtype	oai_dc
spelling	pubmed-30597012011-03-21 The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus Buchanan, Katherine A. Mellor, Jack R. Neuroscience Synaptic plasticity has historically been investigated most intensely in the hippocampus and therefore it is somewhat surprising that the majority of studies on spike timing-dependent plasticity (STDP) have focused not in the hippocampus but on synapses in the cortex. One of the major reasons for this bias is the relative ease in obtaining paired electrophysiological recordings from synaptically coupled neurons in cortical slices, in comparison to hippocampal slices. Another less obvious reason has been the difficulty in achieving reliable STDP in the hippocampal slice preparation and confusion surrounding the conditions required. The original descriptions of STDP in the hippocampus was performed on paired recordings from neurons in dissociated or slice cultures utilizing single pairs of presynaptic and postsynaptic spikes and were subsequently replicated in acute hippocampal slices. Further work in several laboratories using conditions that more closely replicate the situation in vivo revealed a requirement for multiple postsynaptic spikes that necessarily complicate the absolute timing rules for STDP. Here we review the hippocampal STDP literature focusing on data from acute hippocampal slice preparations and highlighting apparently contradictory results and the variations in experimental conditions that might account for the discrepancies. We conclude by relating the majority of the available experimental data to a model for STDP induction in the hippocampus based on a critical role for postsynaptic Ca2+ dynamics. Frontiers Research Foundation 2010-06-07 /pmc/articles/PMC3059701/ /pubmed/21423497 http://dx.doi.org/10.3389/fnsyn.2010.00011 Text en Copyright © 2010 Buchanan and Mellor. http://www.frontiersin.org/licenseagreement This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Buchanan, Katherine A. Mellor, Jack R.
spellingShingle	Buchanan, Katherine A. Mellor, Jack R. The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus
author_facet	Buchanan, Katherine A. Mellor, Jack R.
author_sort	Buchanan, Katherine A.
title	The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus
title_short	The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus
title_full	The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus
title_fullStr	The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus
title_full_unstemmed	The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus
title_sort	activity requirements for spike timing-dependent plasticity in the hippocampus
description	Synaptic plasticity has historically been investigated most intensely in the hippocampus and therefore it is somewhat surprising that the majority of studies on spike timing-dependent plasticity (STDP) have focused not in the hippocampus but on synapses in the cortex. One of the major reasons for this bias is the relative ease in obtaining paired electrophysiological recordings from synaptically coupled neurons in cortical slices, in comparison to hippocampal slices. Another less obvious reason has been the difficulty in achieving reliable STDP in the hippocampal slice preparation and confusion surrounding the conditions required. The original descriptions of STDP in the hippocampus was performed on paired recordings from neurons in dissociated or slice cultures utilizing single pairs of presynaptic and postsynaptic spikes and were subsequently replicated in acute hippocampal slices. Further work in several laboratories using conditions that more closely replicate the situation in vivo revealed a requirement for multiple postsynaptic spikes that necessarily complicate the absolute timing rules for STDP. Here we review the hippocampal STDP literature focusing on data from acute hippocampal slice preparations and highlighting apparently contradictory results and the variations in experimental conditions that might account for the discrepancies. We conclude by relating the majority of the available experimental data to a model for STDP induction in the hippocampus based on a critical role for postsynaptic Ca2+ dynamics.
publisher	Frontiers Research Foundation
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059701/
_version_	1611445911363256320

The Activity Requirements for Spike Timing-Dependent Plasticity in the Hippocampus

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