A Ca2+-Based Computational Model for NMDA Receptor-Dependent Synaptic Plasticity at Individual Post-Synaptic Spines in the Hippocampus

A Ca2+-Based Computational Model for NMDA Receptor-Dependent Synaptic Plasticity at Individual Post-Synaptic Spines in the Hippocampus

Associative synaptic plasticity is synapse specific and requires coincident activity in pre-synaptic and post-synaptic neurons to activate NMDA receptors (NMDARs). The resultant Ca2+ influx is the critical trigger for the induction of synaptic plasticity. Given its centrality for the induction of sy...

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Bibliographic Details
Main Authors: Rackham, Owen J. L., Tsaneva-Atanasova, Krasimira, Ganesh, Ayalvadi, Mellor, Jack R.
Format: Online
Language:English
Published: Frontiers Research Foundation 2010
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059685/

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