The draft genome of the parasitic nematode Trichinella spiralis

Genome-based studies of metazoan evolution are most informative when phylogenetically diverse species are incorporated in the analysis. As such, evolutionary trends within and outside the phylum Nematoda have been less revealing by focusing only on comparisons involving Caenorhabditis elegans. Herei...

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Main Authors:	Mitreva, Makedonka, Jasmer, Douglas P., Zarlenga, Dante S., Wang, Zhengyuan, Abubucker, Sahar, Martin, John, Taylor, Christina M., Yin, Yong, Fulton, Lucinda, Minx, Pat, Yang, Shiaw-Pyng, Warren, Wesley C., Fulton, Robert S., Bhonagiri, Veena, Zhang, Xu, Hallsworth-Pepin, Kym, Clifton, Sandra W., McCarter, James P., Appleton, Judith, Mardis, Elaine R., Wilson, Richard K.
Format:	Online
Language:	English
Published:	2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057868/

id	pubmed-3057868
recordtype	oai_dc
spelling	pubmed-30578682011-09-01 The draft genome of the parasitic nematode Trichinella spiralis Mitreva, Makedonka Jasmer, Douglas P. Zarlenga, Dante S. Wang, Zhengyuan Abubucker, Sahar Martin, John Taylor, Christina M. Yin, Yong Fulton, Lucinda Minx, Pat Yang, Shiaw-Pyng Warren, Wesley C. Fulton, Robert S. Bhonagiri, Veena Zhang, Xu Hallsworth-Pepin, Kym Clifton, Sandra W. McCarter, James P. Appleton, Judith Mardis, Elaine R. Wilson, Richard K. Article Genome-based studies of metazoan evolution are most informative when phylogenetically diverse species are incorporated in the analysis. As such, evolutionary trends within and outside the phylum Nematoda have been less revealing by focusing only on comparisons involving Caenorhabditis elegans. Herein, we present a draft of the 64 megabase nuclear genome of Trichinella spiralis, containing 15,808 protein coding genes. This parasitic nematode is an extant member of a clade that diverged early in the evolution of the phylum enabling identification of archetypical genes and molecular signatures exclusive to nematodes. Comparative analyses support intrachromosomal rearrangements across the phylum, disproportionate numbers of protein family deaths over births in parasitic vs. a non-parasitic nematode, and a preponderance of gene loss and gain events in nematodes relative to Drosophila melanogaster. This sequence and the panphylum characteristics identified herein will advance evolutionary studies and strategies to combat global parasites of humans, food animals and crops. 2011-02-20 2011-03 /pmc/articles/PMC3057868/ /pubmed/21336279 http://dx.doi.org/10.1038/ng.769 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Mitreva, Makedonka Jasmer, Douglas P. Zarlenga, Dante S. Wang, Zhengyuan Abubucker, Sahar Martin, John Taylor, Christina M. Yin, Yong Fulton, Lucinda Minx, Pat Yang, Shiaw-Pyng Warren, Wesley C. Fulton, Robert S. Bhonagiri, Veena Zhang, Xu Hallsworth-Pepin, Kym Clifton, Sandra W. McCarter, James P. Appleton, Judith Mardis, Elaine R. Wilson, Richard K.
spellingShingle	Mitreva, Makedonka Jasmer, Douglas P. Zarlenga, Dante S. Wang, Zhengyuan Abubucker, Sahar Martin, John Taylor, Christina M. Yin, Yong Fulton, Lucinda Minx, Pat Yang, Shiaw-Pyng Warren, Wesley C. Fulton, Robert S. Bhonagiri, Veena Zhang, Xu Hallsworth-Pepin, Kym Clifton, Sandra W. McCarter, James P. Appleton, Judith Mardis, Elaine R. Wilson, Richard K. The draft genome of the parasitic nematode Trichinella spiralis
author_facet	Mitreva, Makedonka Jasmer, Douglas P. Zarlenga, Dante S. Wang, Zhengyuan Abubucker, Sahar Martin, John Taylor, Christina M. Yin, Yong Fulton, Lucinda Minx, Pat Yang, Shiaw-Pyng Warren, Wesley C. Fulton, Robert S. Bhonagiri, Veena Zhang, Xu Hallsworth-Pepin, Kym Clifton, Sandra W. McCarter, James P. Appleton, Judith Mardis, Elaine R. Wilson, Richard K.
author_sort	Mitreva, Makedonka
title	The draft genome of the parasitic nematode Trichinella spiralis
title_short	The draft genome of the parasitic nematode Trichinella spiralis
title_full	The draft genome of the parasitic nematode Trichinella spiralis
title_fullStr	The draft genome of the parasitic nematode Trichinella spiralis
title_full_unstemmed	The draft genome of the parasitic nematode Trichinella spiralis
title_sort	draft genome of the parasitic nematode trichinella spiralis
description	Genome-based studies of metazoan evolution are most informative when phylogenetically diverse species are incorporated in the analysis. As such, evolutionary trends within and outside the phylum Nematoda have been less revealing by focusing only on comparisons involving Caenorhabditis elegans. Herein, we present a draft of the 64 megabase nuclear genome of Trichinella spiralis, containing 15,808 protein coding genes. This parasitic nematode is an extant member of a clade that diverged early in the evolution of the phylum enabling identification of archetypical genes and molecular signatures exclusive to nematodes. Comparative analyses support intrachromosomal rearrangements across the phylum, disproportionate numbers of protein family deaths over births in parasitic vs. a non-parasitic nematode, and a preponderance of gene loss and gain events in nematodes relative to Drosophila melanogaster. This sequence and the panphylum characteristics identified herein will advance evolutionary studies and strategies to combat global parasites of humans, food animals and crops.
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057868/
_version_	1611445603625074688

The draft genome of the parasitic nematode Trichinella spiralis

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