The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations
Research on apolipoprotein E (APOE) has consistently revealed a relationship between the gene's ε4 allele and risk for development of Alzheimer's disease (AD). However, research with younger populations of ε4 carriers has suggested that the APOE ε4 allele may in fact be beneficial in earli...
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| Format: | Online |
| Language: | English |
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SAGE-Hindawi Access to Research
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056453/ |
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pubmed-30564532011-03-21 The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations Tuminello, Elizabeth R. Han, S. Duke Review Article Research on apolipoprotein E (APOE) has consistently revealed a relationship between the gene's ε4 allele and risk for development of Alzheimer's disease (AD). However, research with younger populations of ε4 carriers has suggested that the APOE ε4 allele may in fact be beneficial in earlier ages and may only confer risk of cognitive decline later in life. Accordingly, we and others have proposed that APOE may represent an example of antagonistic pleiotropy. Antagonistic pleiotropy is an evolutionary biology concept that proposes certain genes or alleles that may differentially impact fitness during different life stages. We critically review this hypothesis in light of new research of the impact of APOE on cognition and neural integrity across the lifespan. We provide recommendations for the revision of the antagonistic pleiotropy hypothesis of APOE and suggest important avenues for future research in this area. SAGE-Hindawi Access to Research 2011-02-24 /pmc/articles/PMC3056453/ /pubmed/21423560 http://dx.doi.org/10.4061/2011/726197 Text en Copyright © 2011 E. R. Tuminello and S. D. Han. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Tuminello, Elizabeth R. Han, S. Duke |
| spellingShingle |
Tuminello, Elizabeth R. Han, S. Duke The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations |
| author_facet |
Tuminello, Elizabeth R. Han, S. Duke |
| author_sort |
Tuminello, Elizabeth R. |
| title |
The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations |
| title_short |
The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations |
| title_full |
The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations |
| title_fullStr |
The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations |
| title_full_unstemmed |
The Apolipoprotein E Antagonistic Pleiotropy Hypothesis: Review and Recommendations |
| title_sort |
apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations |
| description |
Research on apolipoprotein E (APOE) has consistently revealed a relationship between the gene's ε4 allele and risk for development of Alzheimer's disease (AD). However, research with younger populations of ε4 carriers has suggested that the APOE ε4 allele may in fact be beneficial in earlier ages and may only confer risk of cognitive decline later in life. Accordingly, we and others have proposed that APOE may represent an example of antagonistic pleiotropy. Antagonistic pleiotropy is an evolutionary biology concept that proposes certain genes or alleles that may differentially impact fitness during different life stages. We critically review this hypothesis in light of new research of the impact of APOE on cognition and neural integrity across the lifespan. We provide recommendations for the revision of the antagonistic pleiotropy hypothesis of APOE and suggest important avenues for future research in this area. |
| publisher |
SAGE-Hindawi Access to Research |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056453/ |
| _version_ |
1611445370972274688 |