The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.

The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus, it has been speculated that the incidence of unexpected antibody against the Di(a) antigen might be relati...

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Main Authors:	Park, Tae Sung, Oh, Seung Hwan, Choi, Jae Cheol, Lee, Dae Dong, Kim, Hyung Hoi, Chang, Chulhun L., Lee, Eun Yup, Son, Han Chul
Format:	Online
Language:	English
Published:	Korean Academy of Medical Sciences 2003
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055118/

id	pubmed-3055118
recordtype	oai_dc
spelling	pubmed-30551182011-03-15 The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations. Park, Tae Sung Oh, Seung Hwan Choi, Jae Cheol Lee, Dae Dong Kim, Hyung Hoi Chang, Chulhun L. Lee, Eun Yup Son, Han Chul Research Article The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus, it has been speculated that the incidence of unexpected antibody against the Di(a) antigen might be relatively higher among these populations. Hemolytic transfusion reactions (HTRs) and hemolytic disease of the newborns (HDNs) caused by anti-Di(a) have been reported sporadically. However, there has been no prospective study on the incidence of anti-Di(a) in Mongoloid populations particularly. The authors conducted a series of antibody screening tests on 11,219 Korean individuals for 25 months, by using three kinds of screening cells including Di(a) cell. Anti-Di(a) was detected in 8 patients, seven of whom had a history of transfusions or were multigravida. The incidence of anti-Di(a) measured in this study was higher than expected, ranked third among unexpected antibodies identified during the period of the study, so it is strongly recommended that the Di(a+) panel cell must be incorporated into antibody screening test for safer transfusion in Asian-Mongoloid populations. Korean Academy of Medical Sciences 2003-10 /pmc/articles/PMC3055118/ /pubmed/14555818 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Park, Tae Sung Oh, Seung Hwan Choi, Jae Cheol Lee, Dae Dong Kim, Hyung Hoi Chang, Chulhun L. Lee, Eun Yup Son, Han Chul
spellingShingle	Park, Tae Sung Oh, Seung Hwan Choi, Jae Cheol Lee, Dae Dong Kim, Hyung Hoi Chang, Chulhun L. Lee, Eun Yup Son, Han Chul The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.
author_facet	Park, Tae Sung Oh, Seung Hwan Choi, Jae Cheol Lee, Dae Dong Kim, Hyung Hoi Chang, Chulhun L. Lee, Eun Yup Son, Han Chul
author_sort	Park, Tae Sung
title	The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.
title_short	The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.
title_full	The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.
title_fullStr	The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.
title_full_unstemmed	The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.
title_sort	clinical significance of antibody screening test including dia+ panel cell in asian-mongoloid populations.
description	The Di(a) antigen is well known as one of the antigens with low incidence among Caucasians; however, it has been discovered with a relatively higher incidence among Mongoloid populations. Thus, it has been speculated that the incidence of unexpected antibody against the Di(a) antigen might be relatively higher among these populations. Hemolytic transfusion reactions (HTRs) and hemolytic disease of the newborns (HDNs) caused by anti-Di(a) have been reported sporadically. However, there has been no prospective study on the incidence of anti-Di(a) in Mongoloid populations particularly. The authors conducted a series of antibody screening tests on 11,219 Korean individuals for 25 months, by using three kinds of screening cells including Di(a) cell. Anti-Di(a) was detected in 8 patients, seven of whom had a history of transfusions or were multigravida. The incidence of anti-Di(a) measured in this study was higher than expected, ranked third among unexpected antibodies identified during the period of the study, so it is strongly recommended that the Di(a+) panel cell must be incorporated into antibody screening test for safer transfusion in Asian-Mongoloid populations.
publisher	Korean Academy of Medical Sciences
publishDate	2003
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055118/
_version_	1611445120264044544

The clinical significance of antibody screening test including Dia+ panel cell in Asian-Mongoloid populations.

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