Congenital cytomegalovirus infection: three autopsy case reports.

Congenital cytomegalovirus infection: three autopsy case reports.

We report three autopsy cases of congenital cytomegalovirus (CMV) infection in fetuses with a review of literature. The clinical manifestations in these cases of congenital CMV infection include intrauterine fetal death, hydrops fetalis, and CMV pneumonia associated with cardiovascular defect. The p...

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Main Authors: Ko, H. M., Kim, K. S., Park, J. W., Lee, Y. J., Lee, M. Y., Lee, M. C., Park, C. S., Juhng, S. W., Choi, C.
Format: Online
Language:English
Published: Korean Academy of Medical Sciences 2000
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054627/
id pubmed-3054627
recordtype oai_dc
spelling pubmed-30546272011-03-15 Congenital cytomegalovirus infection: three autopsy case reports. Ko, H. M. Kim, K. S. Park, J. W. Lee, Y. J. Lee, M. Y. Lee, M. C. Park, C. S. Juhng, S. W. Choi, C. Research Article We report three autopsy cases of congenital cytomegalovirus (CMV) infection in fetuses with a review of literature. The clinical manifestations in these cases of congenital CMV infection include intrauterine fetal death, hydrops fetalis, and CMV pneumonia associated with cardiovascular defect. The pathological characteristics were as follows: 1) the kidney was the most frequently involved organ, followed by lung and liver, 2) CMV inclusions were found predominantly in epithelial cells and to a lesser degree in endothelial cells, 3) intrahepatic bile duct epithelial cells were frequently involved, and 4) inflammatory reaction around CMV inclusions was not prominent in the early stage of pregnancy. Diagnostic confirmation was obtained by in situ hybridization (ISH) using a biotinylated CMV-DNA probe, which demonstrated intranuclear inclusions and sometimes recognized cells that did not show intranuclear inclusion. Korean Academy of Medical Sciences 2000-06 /pmc/articles/PMC3054627/ /pubmed/10895978 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ko, H. M.
Kim, K. S.
Park, J. W.
Lee, Y. J.
Lee, M. Y.
Lee, M. C.
Park, C. S.
Juhng, S. W.
Choi, C.
spellingShingle Ko, H. M.
Kim, K. S.
Park, J. W.
Lee, Y. J.
Lee, M. Y.
Lee, M. C.
Park, C. S.
Juhng, S. W.
Choi, C.
Congenital cytomegalovirus infection: three autopsy case reports.
author_facet Ko, H. M.
Kim, K. S.
Park, J. W.
Lee, Y. J.
Lee, M. Y.
Lee, M. C.
Park, C. S.
Juhng, S. W.
Choi, C.
author_sort Ko, H. M.
title Congenital cytomegalovirus infection: three autopsy case reports.
title_short Congenital cytomegalovirus infection: three autopsy case reports.
title_full Congenital cytomegalovirus infection: three autopsy case reports.
title_fullStr Congenital cytomegalovirus infection: three autopsy case reports.
title_full_unstemmed Congenital cytomegalovirus infection: three autopsy case reports.
title_sort congenital cytomegalovirus infection: three autopsy case reports.
description We report three autopsy cases of congenital cytomegalovirus (CMV) infection in fetuses with a review of literature. The clinical manifestations in these cases of congenital CMV infection include intrauterine fetal death, hydrops fetalis, and CMV pneumonia associated with cardiovascular defect. The pathological characteristics were as follows: 1) the kidney was the most frequently involved organ, followed by lung and liver, 2) CMV inclusions were found predominantly in epithelial cells and to a lesser degree in endothelial cells, 3) intrahepatic bile duct epithelial cells were frequently involved, and 4) inflammatory reaction around CMV inclusions was not prominent in the early stage of pregnancy. Diagnostic confirmation was obtained by in situ hybridization (ISH) using a biotinylated CMV-DNA probe, which demonstrated intranuclear inclusions and sometimes recognized cells that did not show intranuclear inclusion.
publisher Korean Academy of Medical Sciences
publishDate 2000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054627/
_version_ 1611444834232434688

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