Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium.
The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 e...
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| Format: | Online |
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Korean Academy of Medical Sciences
2000
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054585/ |
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pubmed-3054585 |
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pubmed-30545852011-03-15 Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. Research Article The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 expressions by immunohistochemical staining using 2 polydonal COX-1 and COX-2 antibodies. In RA synovia, synovial lining cells showed intense immunostaining for COX-1, whereas slight to moderate staining was observed in inflammatory cells, stromal fibroblast-like cells and vascular endothelial cells. There was no significant difference in COX-1 expression between RA and OA synovia. The localization of COX-2 expression dearly differed from that of COX-1 expression, being most intense in inflammatory cells. However, there was no difference in COX-1 and COX-2 expressions between RA and OA synovial tissues. Our observations support that inflammatory mechanisms modulated by COX-1 and COX-2 in chronic RA synovium might be similar to those in chronic OA synovium. Korean Academy of Medical Sciences 2000-02 /pmc/articles/PMC3054585/ /pubmed/10719816 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. |
| spellingShingle |
Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| author_facet |
Lee, Y. H. Choi, S. J. Kim, A. Kim, C. H. Ji, J. D. Song, G. G. |
| author_sort |
Lee, Y. H. |
| title |
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| title_short |
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| title_full |
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| title_fullStr |
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| title_full_unstemmed |
Expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| title_sort |
expression of cyclooxygenase-1 and -2 in rheumatoid arthritis synovium. |
| description |
The aim of this study was to investigate the expression and localization of cyclooxygenase-1 and -2 (COX-1 and COX-2) in synovial tissues from patients with rheumatoid arthritis (RA). Synovial tissues from 9 patients with RA and 5 patients with osteoarthritis (OA) were examined for COX-1 and COX-2 expressions by immunohistochemical staining using 2 polydonal COX-1 and COX-2 antibodies. In RA synovia, synovial lining cells showed intense immunostaining for COX-1, whereas slight to moderate staining was observed in inflammatory cells, stromal fibroblast-like cells and vascular endothelial cells. There was no significant difference in COX-1 expression between RA and OA synovia. The localization of COX-2 expression dearly differed from that of COX-1 expression, being most intense in inflammatory cells. However, there was no difference in COX-1 and COX-2 expressions between RA and OA synovial tissues. Our observations support that inflammatory mechanisms modulated by COX-1 and COX-2 in chronic RA synovium might be similar to those in chronic OA synovium. |
| publisher |
Korean Academy of Medical Sciences |
| publishDate |
2000 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054585/ |
| _version_ |
1611444809017327616 |