Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.

Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.

Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent deregulation of the cell cycle are frequently involved in tumorigenesis and/or tumor progression. We investigated the expression of...

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Main Authors: Ahn, M. J., Kim, B. H., Jang, S. J., Hong, E. K., Lee, W. M., Baik, H. K., Park, H. K., Lee, C. B., Ki, M.
Format: Online
Language:English
Published: Korean Academy of Medical Sciences 1998
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054530/
id pubmed-3054530
recordtype oai_dc
spelling pubmed-30545302011-03-15 Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance. Ahn, M. J. Kim, B. H. Jang, S. J. Hong, E. K. Lee, W. M. Baik, H. K. Park, H. K. Lee, C. B. Ki, M. Research Article Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent deregulation of the cell cycle are frequently involved in tumorigenesis and/or tumor progression. We investigated the expression of cyclin D1 and cyclin E protein in 84 gastric carcinoma by immunohistochemical staining and also the relevance of each cyclin expression to the clinical outcomes. Overexpression of cyclin D1 and cyclin E was noted in 21 of 84 (25.0%) and 34 of 84 (40.5%) gastric cancer tissues, respectively. There was a significant correlation between overexpression of cyclin E and lymph node metastasis (p=0.003), recurrence (p=0.043), disease free survival (p=0.0378) and overall survival (p=0.0319), but no correlation was noted between overexpression of cyclin D1 and other clinicopathologic variables. These findings suggest that overexpression of cyclin E and cyclin D1 is a frequent finding in gastric cancer and immunohistochemical analysis for cell cycle regulators, especially cyclin E might be a useful prognostic indicator in gastric cancer. Korean Academy of Medical Sciences 1998-10 /pmc/articles/PMC3054530/ /pubmed/9811181 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Ahn, M. J.
Kim, B. H.
Jang, S. J.
Hong, E. K.
Lee, W. M.
Baik, H. K.
Park, H. K.
Lee, C. B.
Ki, M.
spellingShingle Ahn, M. J.
Kim, B. H.
Jang, S. J.
Hong, E. K.
Lee, W. M.
Baik, H. K.
Park, H. K.
Lee, C. B.
Ki, M.
Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
author_facet Ahn, M. J.
Kim, B. H.
Jang, S. J.
Hong, E. K.
Lee, W. M.
Baik, H. K.
Park, H. K.
Lee, C. B.
Ki, M.
author_sort Ahn, M. J.
title Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
title_short Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
title_full Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
title_fullStr Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
title_full_unstemmed Expression of cyclin D1 and cyclin E in human gastric carcinoma and its clinicopathologic significance.
title_sort expression of cyclin d1 and cyclin e in human gastric carcinoma and its clinicopathologic significance.
description Cyclin D1 and cyclin E are the mammalian G1 cydins that are both required and rate limiting for entry into S phase. Alterations in cell cycle regulators and subsequent deregulation of the cell cycle are frequently involved in tumorigenesis and/or tumor progression. We investigated the expression of cyclin D1 and cyclin E protein in 84 gastric carcinoma by immunohistochemical staining and also the relevance of each cyclin expression to the clinical outcomes. Overexpression of cyclin D1 and cyclin E was noted in 21 of 84 (25.0%) and 34 of 84 (40.5%) gastric cancer tissues, respectively. There was a significant correlation between overexpression of cyclin E and lymph node metastasis (p=0.003), recurrence (p=0.043), disease free survival (p=0.0378) and overall survival (p=0.0319), but no correlation was noted between overexpression of cyclin D1 and other clinicopathologic variables. These findings suggest that overexpression of cyclin E and cyclin D1 is a frequent finding in gastric cancer and immunohistochemical analysis for cell cycle regulators, especially cyclin E might be a useful prognostic indicator in gastric cancer.
publisher Korean Academy of Medical Sciences
publishDate 1998
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054530/
_version_ 1611444777657565184

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