Adenovirus-mediated p53 tumor suppressor gene therapy against subcutaneous HuH7 hepatoma cell line nodule of nude mice.

Adenovirus-mediated p53 tumor suppressor gene therapy against subcutaneous HuH7 hepatoma cell line nodule of nude mice.

Mutations of the tumor-suppressor gene p53 have been found in 30-50% cases of hepatocellular carcinoma (HCC). In this study, E1-negative adenoviral vector encoding wild-type p53 under the control of the human cytomegalovirus promoter (AdCMV-p53w) was constructed to evaluate its therapeutic efficacy...

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Bibliographic Details
Main Authors: Choi, J. Y., Park, Y. M., Byun, B. H., Kim, B. S., Hong, E. G., Shin, D. Y., Seong, Y. R., Im, D. S.
Format: Online
Language:English
Published: Korean Academy of Medical Sciences 1999
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054385/

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