The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives.
Following the acute diarrhea in patients (n = 24) overnight with commonly used laxatives for bowel preparation, the changes in electrolytes and acid-base balance in blood and urine were investigated. Though no alterations of serum sodium or potassium concentrations were noted, mild but significant r...
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Korean Academy of Medical Sciences
1994
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054202/ |
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pubmed-3054202 |
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pubmed-30542022011-03-15 The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. Kim, H. J. Yoon, Y. M. Park, K. N. Research Article Following the acute diarrhea in patients (n = 24) overnight with commonly used laxatives for bowel preparation, the changes in electrolytes and acid-base balance in blood and urine were investigated. Though no alterations of serum sodium or potassium concentrations were noted, mild but significant reduction of mean values (+/- SEM) of plasma pH and HCO3 after diarrhea when compared to those before it developed (pH, from 7.42 +/- 0.01 to 7.39 +/- 0.01, p < 0.01; HCO3, from 25.8 +/- 0.6 to 23.7 +/- 0.6 mEq/L, p < 0.05). However, significant reduction of concentration in spot urine sodium from 150 +/- 12.3 to 93 +/- 14 mEq/g of crea. (p < 0.01) and increase in spot urine potassium from 33 +/- 3.2 to 51 +/- 6.0 mEq/g of crea. (p < 0.05) following diarrhea were seen with significant reduction of urine pH from 6.67 +/- 0.21 to 5.5 +/- 0.13 (p < 0.001). Also, with this effective urinary acidification following diarrhea, a significant reduction of urinary anion gap as well as significant increment of spot urine ammonium was accompanied (anion gap, from 80.4 +/- 11.1 to 44 +/- 8.5 mEq/g of crea. p < 0.001; ammonium, from 87 +/- 18.5 to 229 +/- 37 mg/g of crea. p < 0.001) in addition to the significant inverse correlation between these changes in spot urine from basal levels in 24 study subjects (y = -1.13 x +61, r = 0.7, p < 0.001). In conclusion, we observed that the acute diarrhea with laxatives used for bowel preparation caused a mild degree of metabolic acidosis with no changes in blood electrolytes.(ABSTRACT TRUNCATED AT 250 WORDS) Korean Academy of Medical Sciences 1994-10 /pmc/articles/PMC3054202/ /pubmed/7702787 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, H. J. Yoon, Y. M. Park, K. N. |
| spellingShingle |
Kim, H. J. Yoon, Y. M. Park, K. N. The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| author_facet |
Kim, H. J. Yoon, Y. M. Park, K. N. |
| author_sort |
Kim, H. J. |
| title |
The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| title_short |
The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| title_full |
The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| title_fullStr |
The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| title_full_unstemmed |
The changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| title_sort |
changes in electrolytes and acid-base balance after artificially induced acute diarrhea by laxatives. |
| description |
Following the acute diarrhea in patients (n = 24) overnight with commonly used laxatives for bowel preparation, the changes in electrolytes and acid-base balance in blood and urine were investigated. Though no alterations of serum sodium or potassium concentrations were noted, mild but significant reduction of mean values (+/- SEM) of plasma pH and HCO3 after diarrhea when compared to those before it developed (pH, from 7.42 +/- 0.01 to 7.39 +/- 0.01, p < 0.01; HCO3, from 25.8 +/- 0.6 to 23.7 +/- 0.6 mEq/L, p < 0.05). However, significant reduction of concentration in spot urine sodium from 150 +/- 12.3 to 93 +/- 14 mEq/g of crea. (p < 0.01) and increase in spot urine potassium from 33 +/- 3.2 to 51 +/- 6.0 mEq/g of crea. (p < 0.05) following diarrhea were seen with significant reduction of urine pH from 6.67 +/- 0.21 to 5.5 +/- 0.13 (p < 0.001). Also, with this effective urinary acidification following diarrhea, a significant reduction of urinary anion gap as well as significant increment of spot urine ammonium was accompanied (anion gap, from 80.4 +/- 11.1 to 44 +/- 8.5 mEq/g of crea. p < 0.001; ammonium, from 87 +/- 18.5 to 229 +/- 37 mg/g of crea. p < 0.001) in addition to the significant inverse correlation between these changes in spot urine from basal levels in 24 study subjects (y = -1.13 x +61, r = 0.7, p < 0.001). In conclusion, we observed that the acute diarrhea with laxatives used for bowel preparation caused a mild degree of metabolic acidosis with no changes in blood electrolytes.(ABSTRACT TRUNCATED AT 250 WORDS) |
| publisher |
Korean Academy of Medical Sciences |
| publishDate |
1994 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3054202/ |
| _version_ |
1611444587046371328 |