Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients.
To evaluate the significance of chironomid as a respiratory allergen, we performed skin prick tests with Chironomus plumosus (CP) and Tokunagayusurika akamusi (TA) extracts on 475 respiratory allergy patients, and their specific IgE antibodies were detected by enzyme-linked immunosorbent assay (ELIS...
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Korean Academy of Medical Sciences
1994
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053906/ |
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pubmed-30539062011-03-15 Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. Kim, Y. J. Park, H. S. Research Article To evaluate the significance of chironomid as a respiratory allergen, we performed skin prick tests with Chironomus plumosus (CP) and Tokunagayusurika akamusi (TA) extracts on 475 respiratory allergy patients, and their specific IgE antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in 106 positive reactors to skin prick test and 30 negative controls. Ninety-seven (20.4%) showed more than 2+ of allergen to histamine ratio to CP and 98 (20.6%) to TA on skin prick test. Seventy-one (73.2%) of 97 positive reactors had increased specific IgE to CP, and 34 (34.7%) of 98 positive reactors, to TA. CP-specific IgE was detected in 14 (14.4%) non-atopic asthmatics and 6 (6.2%) non-allergic rhinitis patients. TA-specific IgE was detected in 17 (17.4%) non-atopic asthmatics and 6 (6.1%) non-allergic rhinitis patients. No association was noted between skin reactivity to Dermatophagoides farinae and the prevalence of specific IgE to CP or TA (p > 0.05). The correlation between total IgE level and specific IgE level to CP and TA was poor (r = 0.07, 0.04). ELISA inhibition test suggested specificity of IgE binding and cross-allergenicity between CP and TA. It is suggested that CP and TA can induce IgE-mediated reaction in exposed patients and should be considered as important causative allergens in respiratory allergy patients in Korea. Korean Academy of Medical Sciences 1994-02 /pmc/articles/PMC3053906/ /pubmed/8068215 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kim, Y. J. Park, H. S. |
| spellingShingle |
Kim, Y. J. Park, H. S. Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. |
| author_facet |
Kim, Y. J. Park, H. S. |
| author_sort |
Kim, Y. J. |
| title |
Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. |
| title_short |
Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. |
| title_full |
Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. |
| title_fullStr |
Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. |
| title_full_unstemmed |
Skin reactivity and specific IgE antibody to two nonbiting midges in Korean respiratory allergy patients. |
| title_sort |
skin reactivity and specific ige antibody to two nonbiting midges in korean respiratory allergy patients. |
| description |
To evaluate the significance of chironomid as a respiratory allergen, we performed skin prick tests with Chironomus plumosus (CP) and Tokunagayusurika akamusi (TA) extracts on 475 respiratory allergy patients, and their specific IgE antibodies were detected by enzyme-linked immunosorbent assay (ELISA) in 106 positive reactors to skin prick test and 30 negative controls. Ninety-seven (20.4%) showed more than 2+ of allergen to histamine ratio to CP and 98 (20.6%) to TA on skin prick test. Seventy-one (73.2%) of 97 positive reactors had increased specific IgE to CP, and 34 (34.7%) of 98 positive reactors, to TA. CP-specific IgE was detected in 14 (14.4%) non-atopic asthmatics and 6 (6.2%) non-allergic rhinitis patients. TA-specific IgE was detected in 17 (17.4%) non-atopic asthmatics and 6 (6.1%) non-allergic rhinitis patients. No association was noted between skin reactivity to Dermatophagoides farinae and the prevalence of specific IgE to CP or TA (p > 0.05). The correlation between total IgE level and specific IgE level to CP and TA was poor (r = 0.07, 0.04). ELISA inhibition test suggested specificity of IgE binding and cross-allergenicity between CP and TA. It is suggested that CP and TA can induce IgE-mediated reaction in exposed patients and should be considered as important causative allergens in respiratory allergy patients in Korea. |
| publisher |
Korean Academy of Medical Sciences |
| publishDate |
1994 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053906/ |
| _version_ |
1611444460527288320 |