Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.

Ten brain tumor patients underwent wide resection of the tumor followed by Intraoperative Radiation Therapy (IORT) at the first surgery or at the second salvage surgery after failure of conventional external beam irradiation. Two patients(1 meningioma, 1 glioblastoma multiforme) were treated at the...

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Main Authors:	Chung, Y. G., Kim, C. Y., Lee, H. K., Lee, K. C., Chu, J. W., Choi, M. S.
Format:	Online
Language:	English
Published:	Korean Academy of Medical Sciences 1995
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053885/

id	pubmed-3053885
recordtype	oai_dc
spelling	pubmed-30538852011-03-15 Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors. Chung, Y. G. Kim, C. Y. Lee, H. K. Lee, K. C. Chu, J. W. Choi, M. S. Research Article Ten brain tumor patients underwent wide resection of the tumor followed by Intraoperative Radiation Therapy (IORT) at the first surgery or at the second salvage surgery after failure of conventional external beam irradiation. Two patients(1 meningioma, 1 glioblastoma multiforme) were treated at the first surgery and 8 patients(3 anaplastic astrocytoma, 3 glioblastoma multiforme, 1 meningioma, 1 gliosarcoma) were treated after salvage surgery. The IORT doses were ranged from 15-25 Gy depending on the tumor volume and previous radiation therapy. The neurological status(Karnofsky performance status) was improved in 4 cases, not changed in 6 cases after IORT. There were several complications after IORT; radiation necrosis, communicating hydrocephalus, wound infection, and abnormal CT findings such as diffuse low density area in an around operation site. The radiation necrosis was confirmed by operation in a recurrent meningioma patient 12 months after IORT. At follow-up, ranging from 1 to 16 months, there was no deaths. Based on our limited experiences, the IORT might be one of the adjuvant therapeutic modalities especially for the malignant brain tumors and unresectable huge meningioma. Korean Academy of Medical Sciences 1995-12 /pmc/articles/PMC3053885/ /pubmed/8924231 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Chung, Y. G. Kim, C. Y. Lee, H. K. Lee, K. C. Chu, J. W. Choi, M. S.
spellingShingle	Chung, Y. G. Kim, C. Y. Lee, H. K. Lee, K. C. Chu, J. W. Choi, M. S. Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.
author_facet	Chung, Y. G. Kim, C. Y. Lee, H. K. Lee, K. C. Chu, J. W. Choi, M. S.
author_sort	Chung, Y. G.
title	Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.
title_short	Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.
title_full	Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.
title_fullStr	Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.
title_full_unstemmed	Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.
title_sort	preliminary experiences with intraoperative radiation therapy (iort) for the treatment of brain tumors.
description	Ten brain tumor patients underwent wide resection of the tumor followed by Intraoperative Radiation Therapy (IORT) at the first surgery or at the second salvage surgery after failure of conventional external beam irradiation. Two patients(1 meningioma, 1 glioblastoma multiforme) were treated at the first surgery and 8 patients(3 anaplastic astrocytoma, 3 glioblastoma multiforme, 1 meningioma, 1 gliosarcoma) were treated after salvage surgery. The IORT doses were ranged from 15-25 Gy depending on the tumor volume and previous radiation therapy. The neurological status(Karnofsky performance status) was improved in 4 cases, not changed in 6 cases after IORT. There were several complications after IORT; radiation necrosis, communicating hydrocephalus, wound infection, and abnormal CT findings such as diffuse low density area in an around operation site. The radiation necrosis was confirmed by operation in a recurrent meningioma patient 12 months after IORT. At follow-up, ranging from 1 to 16 months, there was no deaths. Based on our limited experiences, the IORT might be one of the adjuvant therapeutic modalities especially for the malignant brain tumors and unresectable huge meningioma.
publisher	Korean Academy of Medical Sciences
publishDate	1995
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053885/
_version_	1611444448747585536

Preliminary experiences with intraoperative radiation therapy (IORT) for the treatment of brain tumors.

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