Botulinum a toxin treatment of hemifacial spasm and blepharospasm.
We studied the effects of botulinum A toxin in 101 patients with hemifacial spasm and 11 patients with blepharospasm in an open trial and double blind manner. All patients in the open trial and 6 patients in the double blind trial improved after the first injection of botulinum toxin. There was no i...
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| Format: | Online |
| Language: | English |
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Korean Academy of Medical Sciences
1993
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053713/ |
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pubmed-3053713 |
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pubmed-30537132011-03-16 Botulinum a toxin treatment of hemifacial spasm and blepharospasm. Park, Y. C. Lim, J. K. Lee, D. K. Yi, S. D. Research Article We studied the effects of botulinum A toxin in 101 patients with hemifacial spasm and 11 patients with blepharospasm in an open trial and double blind manner. All patients in the open trial and 6 patients in the double blind trial improved after the first injection of botulinum toxin. There was no improvement with placebo. The peak effect ranged from one to 6 days after injection and mean peak effect was 3.6 days in blepharospasm, and 4 days in hemifacial spasm. Of 144 treatments, 98.6% had excellent results, (below grade I). The duration of beneficial effect ranged 11 to 40 weeks (mean 16.5 weeks) in hemifacial spasm and 9 to 30 weeks (mean 14.2 weeks) in blepharospasm. Complications were encountered in 63.4% in hemifacial spasm and 72.7% in blepharospasm. The common side effects were dry eyes, mouth droop, ptosis and lid edema in order of frequency. These side effects were mild and resolved spontaneously in 1 to 3 weeks. Botulinum A toxin therapy is effective and convenient, and the treatment of choice for patients with hemifacial spasm and blepharospasm. Korean Academy of Medical Sciences 1993-10 /pmc/articles/PMC3053713/ /pubmed/8305141 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Park, Y. C. Lim, J. K. Lee, D. K. Yi, S. D. |
| spellingShingle |
Park, Y. C. Lim, J. K. Lee, D. K. Yi, S. D. Botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| author_facet |
Park, Y. C. Lim, J. K. Lee, D. K. Yi, S. D. |
| author_sort |
Park, Y. C. |
| title |
Botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| title_short |
Botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| title_full |
Botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| title_fullStr |
Botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| title_full_unstemmed |
Botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| title_sort |
botulinum a toxin treatment of hemifacial spasm and blepharospasm. |
| description |
We studied the effects of botulinum A toxin in 101 patients with hemifacial spasm and 11 patients with blepharospasm in an open trial and double blind manner. All patients in the open trial and 6 patients in the double blind trial improved after the first injection of botulinum toxin. There was no improvement with placebo. The peak effect ranged from one to 6 days after injection and mean peak effect was 3.6 days in blepharospasm, and 4 days in hemifacial spasm. Of 144 treatments, 98.6% had excellent results, (below grade I). The duration of beneficial effect ranged 11 to 40 weeks (mean 16.5 weeks) in hemifacial spasm and 9 to 30 weeks (mean 14.2 weeks) in blepharospasm. Complications were encountered in 63.4% in hemifacial spasm and 72.7% in blepharospasm. The common side effects were dry eyes, mouth droop, ptosis and lid edema in order of frequency. These side effects were mild and resolved spontaneously in 1 to 3 weeks. Botulinum A toxin therapy is effective and convenient, and the treatment of choice for patients with hemifacial spasm and blepharospasm. |
| publisher |
Korean Academy of Medical Sciences |
| publishDate |
1993 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053713/ |
| _version_ |
1611444347248574464 |