The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease

The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD). We analyzed data of 9,019 Koreans who visited a health check up center. The SUA levels of all of these subjects were within the norma...

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Main Authors:	Hwang, In-Cheol, Suh, Sang-Yeon, Suh, Ah-Ram, Ahn, Hong-Yup
Format:	Online
Language:	English
Published:	The Korean Academy of Medical Sciences 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051086/

id	pubmed-3051086
recordtype	oai_dc
spelling	pubmed-30510862011-03-10 The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease Hwang, In-Cheol Suh, Sang-Yeon Suh, Ah-Ram Ahn, Hong-Yup Original Article The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD). We analyzed data of 9,019 Koreans who visited a health check up center. The SUA levels of all of these subjects were within the normal range. The participants were divided into 4 groups according to the quartiles of the SUA levels for both sexes. Hepatic steatosis was diagnosed on the basis of ultrasonographic findings. Multivariate logistic regression modeling was performed across the SUA quartiles. The presence of NAFLD and metabolic abnormalities were found significantly in subjects with high-normal SUA levels. After adjustment for age, metabolic components, and the liver-function test, the adjusted odds ratio (OR, 95% CIs) for the presence of NAFLD in the subjects with the highest SUA level was 1.46 (1.17-1.82) for men and 2.13 (1.42-3.18) for women, as compared to the subjects with the lowest SUA level. Our results suggest that increased SUA concentrations, even within the normal range, are independently associated with the presence of NAFLD. The Korean Academy of Medical Sciences 2011-03 2011-02-25 /pmc/articles/PMC3051086/ /pubmed/21394307 http://dx.doi.org/10.3346/jkms.2011.26.3.386 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Hwang, In-Cheol Suh, Sang-Yeon Suh, Ah-Ram Ahn, Hong-Yup
spellingShingle	Hwang, In-Cheol Suh, Sang-Yeon Suh, Ah-Ram Ahn, Hong-Yup The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
author_facet	Hwang, In-Cheol Suh, Sang-Yeon Suh, Ah-Ram Ahn, Hong-Yup
author_sort	Hwang, In-Cheol
title	The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
title_short	The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
title_full	The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
title_fullStr	The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
title_full_unstemmed	The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease
title_sort	relationship between normal serum uric acid and nonalcoholic fatty liver disease
description	The objective of the present study was to determine the relationship between serum uric acid (SUA) level and the presence of nonalcoholic fatty liver disease (NAFLD). We analyzed data of 9,019 Koreans who visited a health check up center. The SUA levels of all of these subjects were within the normal range. The participants were divided into 4 groups according to the quartiles of the SUA levels for both sexes. Hepatic steatosis was diagnosed on the basis of ultrasonographic findings. Multivariate logistic regression modeling was performed across the SUA quartiles. The presence of NAFLD and metabolic abnormalities were found significantly in subjects with high-normal SUA levels. After adjustment for age, metabolic components, and the liver-function test, the adjusted odds ratio (OR, 95% CIs) for the presence of NAFLD in the subjects with the highest SUA level was 1.46 (1.17-1.82) for men and 2.13 (1.42-3.18) for women, as compared to the subjects with the lowest SUA level. Our results suggest that increased SUA concentrations, even within the normal range, are independently associated with the presence of NAFLD.
publisher	The Korean Academy of Medical Sciences
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051086/
_version_	1611443481318785024

The Relationship between Normal Serum Uric Acid and Nonalcoholic Fatty Liver Disease

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