PRMT5 is required for cell-cycle progression and p53 tumor suppressor function
Protein arginine methyltransferases (PRMTs) mediate the transfer of methyl groups to arginines in proteins involved in signal transduction, transcriptional regulation and RNA processing. Tumor suppressor p53 coordinates crucial cellular processes, including cell-cycle arrest and DNA repair, in respo...
Main Authors: | , , |
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Format: | Online |
Language: | English |
Published: |
Oxford University Press
2009
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2731901/ |