Heterozygous Mutation of Drosophila Opa1 Causes the Development of Multiple Organ Abnormalities in an Age-Dependent and Organ-Specific Manner
Optic Atrophy 1 (OPA1) is a ubiquitously expressed dynamin-like GTPase in the inner mitochondrial membrane. It plays important roles in mitochondrial fusion, apoptosis, reactive oxygen species (ROS) and ATP production. Mutations of OPA1 result in autosomal dominant optic atrophy (DOA). The molecular...
| Main Authors: | , , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
Public Library of Science
2009
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730818/ |