Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl +/− Mouse, a Model of Cornelia de Lange Syndrome

Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl +/− Mouse, a Model of Cornelia de Lange Syndrome

Cornelia de Lange Syndrome (CdLS) is a multi-organ system birth defects disorder linked, in at least half of cases, to heterozygous mutations in the NIPBL gene. In animals and fungi, orthologs of NIPBL regulate cohesin, a complex of proteins that is essential for chromosome cohesion and is also impl...

Full description

Bibliographic Details
Main Authors: Kawauchi, Shimako, Calof, Anne L., Santos, Rosaysela, Lopez-Burks, Martha E., Young, Clint M., Hoang, Michelle P., Chua, Abigail, Lao, Taotao, Lechner, Mark S., Daniel, Jeremy A., Nussenzweig, Andre, Kitzes, Leonard, Yokomori, Kyoko, Hallgrimsson, Benedikt, Lander, Arthur D.
Format: Online
Language:English
Published: Public Library of Science 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730539/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730539/

Similar Items