Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis

Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription fact...

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Main Authors:	Bureau, Christophe, Hanoun, Naima, Torrisani, Jérôme, Vinel, Jean-Pierre, Buscail, Louis, Cordelier, Pierre
Format:	Online
Language:	English
Published:	Bentham Science Publishers Ltd. 2009
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729999/

id	pubmed-2729999
recordtype	oai_dc
spelling	pubmed-27299992010-02-01 Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis Bureau, Christophe Hanoun, Naima Torrisani, Jérôme Vinel, Jean-Pierre Buscail, Louis Cordelier, Pierre Article Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle regulation. Among them, many up-regulated genes are inhibitors of proliferation, whereas genes that promote cell proliferation are repressed. However, several studies do present KLFs as positive regulator of cell proliferation. KLFs can be deregulated in multiple cancers either by loss of heterozygosity (LOH), somatic mutation or transcriptional silencing by promoter hypermethylation. Accordingly, KLF expression was shown to mediate growth inhibition when ectopically expressed in multiple cancer-derived cell lines through the inhibition of a number of key oncogenic signaling pathways, and to revert the tumorogenic phenotype in vivo. Taken together, these observations suggest that KLFs act as tumor suppressor. However, in some occasion, KLFs could act as tumor promoters, depending on “cellular context”. Thus, this review will discuss the roles and the functions of KLF family members in carcinogenesis, with a special focus on cancers from epithelial origin. Bentham Science Publishers Ltd. 2009-08 /pmc/articles/PMC2729999/ /pubmed/20119532 http://dx.doi.org/10.2174/138920209788921010 Text en ©2009 Bentham Science Publishers Ltd. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Bureau, Christophe Hanoun, Naima Torrisani, Jérôme Vinel, Jean-Pierre Buscail, Louis Cordelier, Pierre
spellingShingle	Bureau, Christophe Hanoun, Naima Torrisani, Jérôme Vinel, Jean-Pierre Buscail, Louis Cordelier, Pierre Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
author_facet	Bureau, Christophe Hanoun, Naima Torrisani, Jérôme Vinel, Jean-Pierre Buscail, Louis Cordelier, Pierre
author_sort	Bureau, Christophe
title	Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
title_short	Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
title_full	Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
title_fullStr	Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
title_full_unstemmed	Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
title_sort	expression and function of kruppel like-factors (klf) in carcinogenesis
description	Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle regulation. Among them, many up-regulated genes are inhibitors of proliferation, whereas genes that promote cell proliferation are repressed. However, several studies do present KLFs as positive regulator of cell proliferation. KLFs can be deregulated in multiple cancers either by loss of heterozygosity (LOH), somatic mutation or transcriptional silencing by promoter hypermethylation. Accordingly, KLF expression was shown to mediate growth inhibition when ectopically expressed in multiple cancer-derived cell lines through the inhibition of a number of key oncogenic signaling pathways, and to revert the tumorogenic phenotype in vivo. Taken together, these observations suggest that KLFs act as tumor suppressor. However, in some occasion, KLFs could act as tumor promoters, depending on “cellular context”. Thus, this review will discuss the roles and the functions of KLF family members in carcinogenesis, with a special focus on cancers from epithelial origin.
publisher	Bentham Science Publishers Ltd.
publishDate	2009
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729999/
_version_	1611442430073110528

Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis

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